Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life
Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines)...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2017-03, Vol.46 (3), p.504-515 |
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| creator | Granot, Tomer Senda, Takashi Carpenter, Dustin J. Matsuoka, Nobuhide Weiner, Joshua Gordon, Claire L. Miron, Michelle Kumar, Brahma V. Griesemer, Adam Ho, Siu-Hong Lerner, Harvey Thome, Joseph J.C. Connors, Thomas Reizis, Boris Farber, Donna L. |
| description | Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141hiCD13hi) and cDC2 (Sirp-α+CD1c+) subsets was a function of tissue site and was conserved between donors. We identified cDC2 as the major mature (HLA-DRhi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal site, reflecting their tissue-migratory origin. These distribution and maturation patterns were largely maintained throughout life, with site-specific variations. Our findings provide evidence for localized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2 functioning as guardians of the mucosa.
[Display omitted]
•Human cDC1 and cDC2 subset distribution is a function of tissue site•cDC2s exhibit maturation and migration phenotypes in mucosal-draining lymph nodes•Mature cDC2s accumulate in lymph node interfollicular zones•Localized cDC subset distribution and maturation is largely retained over life
Dendritic cells (DCs) function as tissue sentinels, but this role is difficult to study in humans. In this issue of Immunity, Granot et al. show through analysis of lymphoid and mucosal tissues that human DC maturation is tissue specific, associated with migration phenotypes, and predominantly observed among the cDC2 subset. |
| doi_str_mv | 10.1016/j.immuni.2017.02.019 |
| format | Article |
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[Display omitted]
•Human cDC1 and cDC2 subset distribution is a function of tissue site•cDC2s exhibit maturation and migration phenotypes in mucosal-draining lymph nodes•Mature cDC2s accumulate in lymph node interfollicular zones•Localized cDC subset distribution and maturation is largely retained over life
Dendritic cells (DCs) function as tissue sentinels, but this role is difficult to study in humans. In this issue of Immunity, Granot et al. show through analysis of lymphoid and mucosal tissues that human DC maturation is tissue specific, associated with migration phenotypes, and predominantly observed among the cDC2 subset.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2017.02.019</identifier><identifier>PMID: 28329707</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age composition ; Aged ; Aged, 80 and over ; Antigens ; Blood & organ donations ; CD1c antigen ; Cdc2 protein ; Cell adhesion & migration ; Child ; Child, Preschool ; Dendritic cells ; Dendritic Cells - cytology ; Division of labor ; Female ; Flow Cytometry ; Fluorescent Antibody Technique ; Histocompatibility antigen HLA ; Homeostasis ; human immunology ; Humans ; Infant ; Intestine ; Lungs ; Lymph nodes ; Lymphatic system ; Lymphocytes ; Male ; Maturation ; Middle Aged ; Mucosa ; mucosal immunity ; Organ donors ; Rodents ; T cell receptors ; tissue immunity ; Tissues ; Young Adult</subject><ispartof>Immunity (Cambridge, Mass.), 2017-03, Vol.46 (3), p.504-515</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 21, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-36d73865cdb8375d8d2655685bc77da5cbc88c1a08f569f514c87229eed6657f3</citedby><cites>FETCH-LOGICAL-c590t-36d73865cdb8375d8d2655685bc77da5cbc88c1a08f569f514c87229eed6657f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S107476131730081X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28329707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Granot, Tomer</creatorcontrib><creatorcontrib>Senda, Takashi</creatorcontrib><creatorcontrib>Carpenter, Dustin J.</creatorcontrib><creatorcontrib>Matsuoka, Nobuhide</creatorcontrib><creatorcontrib>Weiner, Joshua</creatorcontrib><creatorcontrib>Gordon, Claire L.</creatorcontrib><creatorcontrib>Miron, Michelle</creatorcontrib><creatorcontrib>Kumar, Brahma V.</creatorcontrib><creatorcontrib>Griesemer, Adam</creatorcontrib><creatorcontrib>Ho, Siu-Hong</creatorcontrib><creatorcontrib>Lerner, Harvey</creatorcontrib><creatorcontrib>Thome, Joseph J.C.</creatorcontrib><creatorcontrib>Connors, Thomas</creatorcontrib><creatorcontrib>Reizis, Boris</creatorcontrib><creatorcontrib>Farber, Donna L.</creatorcontrib><title>Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141hiCD13hi) and cDC2 (Sirp-α+CD1c+) subsets was a function of tissue site and was conserved between donors. We identified cDC2 as the major mature (HLA-DRhi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal site, reflecting their tissue-migratory origin. These distribution and maturation patterns were largely maintained throughout life, with site-specific variations. Our findings provide evidence for localized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2 functioning as guardians of the mucosa.
[Display omitted]
•Human cDC1 and cDC2 subset distribution is a function of tissue site•cDC2s exhibit maturation and migration phenotypes in mucosal-draining lymph nodes•Mature cDC2s accumulate in lymph node interfollicular zones•Localized cDC subset distribution and maturation is largely retained over life
Dendritic cells (DCs) function as tissue sentinels, but this role is difficult to study in humans. In this issue of Immunity, Granot et al. show through analysis of lymphoid and mucosal tissues that human DC maturation is tissue specific, associated with migration phenotypes, and predominantly observed among the cDC2 subset.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age composition</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Blood & organ donations</subject><subject>CD1c antigen</subject><subject>Cdc2 protein</subject><subject>Cell adhesion & migration</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - cytology</subject><subject>Division of labor</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescent Antibody Technique</subject><subject>Histocompatibility antigen HLA</subject><subject>Homeostasis</subject><subject>human immunology</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestine</subject><subject>Lungs</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Maturation</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>mucosal immunity</subject><subject>Organ donors</subject><subject>Rodents</subject><subject>T cell receptors</subject><subject>tissue immunity</subject><subject>Tissues</subject><subject>Young Adult</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EoqXwDxCyxKWXBNvxVy5IaBdopUUcWrhajj0BrxJnsZOV9t_j1bbl44A4eSQ_887M-yL0kpKaEirfbOswjksMNSNU1YTVhLaP0Dklrao41eTxsVa8UpI2Z-hZzltCKBcteYrOmG5Yq4g6R1_XEH0Kc3B4BcOQ8Trk3WAP-GbpMszYRo9vQ84LVDc7cKEv4Cc7L8nOYYp4fYh2DC7jaQ8JXy2jjXgTeniOnvR2yPDi7r1AXz68v11dVZvPH69X7zaVK4vMVSO9arQUzne6UcJrz6QQUovOKeWtcJ3T2lFLdC9k2wvKnVaMtQBeSqH65gK9Penulm4E7yDOyQ5ml8Jo08FMNpg_f2L4br5NeyM4FQ3RReDyTiBNPxbIsxlDdsUJG2FasqFa61YSwfj_oIRLxTkr6Ou_0O20pFicOFKcybawheInyqUp5wT9w96UmGPGZmtOGZtjxoYwUzIuba9-v_mh6T7UX6ZAcX4fIJnsAkQHPiRws_FT-PeEn9qWucU</recordid><startdate>20170321</startdate><enddate>20170321</enddate><creator>Granot, Tomer</creator><creator>Senda, Takashi</creator><creator>Carpenter, Dustin J.</creator><creator>Matsuoka, Nobuhide</creator><creator>Weiner, Joshua</creator><creator>Gordon, Claire L.</creator><creator>Miron, Michelle</creator><creator>Kumar, Brahma V.</creator><creator>Griesemer, Adam</creator><creator>Ho, Siu-Hong</creator><creator>Lerner, Harvey</creator><creator>Thome, Joseph J.C.</creator><creator>Connors, Thomas</creator><creator>Reizis, Boris</creator><creator>Farber, Donna L.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170321</creationdate><title>Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life</title><author>Granot, Tomer ; Senda, Takashi ; Carpenter, Dustin J. ; Matsuoka, Nobuhide ; Weiner, Joshua ; Gordon, Claire L. ; Miron, Michelle ; Kumar, Brahma V. ; Griesemer, Adam ; Ho, Siu-Hong ; Lerner, Harvey ; Thome, Joseph J.C. ; Connors, Thomas ; Reizis, Boris ; Farber, Donna L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-36d73865cdb8375d8d2655685bc77da5cbc88c1a08f569f514c87229eed6657f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age composition</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Blood & organ donations</topic><topic>CD1c antigen</topic><topic>Cdc2 protein</topic><topic>Cell adhesion & migration</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Granot, Tomer</au><au>Senda, Takashi</au><au>Carpenter, Dustin J.</au><au>Matsuoka, Nobuhide</au><au>Weiner, Joshua</au><au>Gordon, Claire L.</au><au>Miron, Michelle</au><au>Kumar, Brahma V.</au><au>Griesemer, Adam</au><au>Ho, Siu-Hong</au><au>Lerner, Harvey</au><au>Thome, Joseph J.C.</au><au>Connors, Thomas</au><au>Reizis, Boris</au><au>Farber, Donna L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2017-03-21</date><risdate>2017</risdate><volume>46</volume><issue>3</issue><spage>504</spage><epage>515</epage><pages>504-515</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141hiCD13hi) and cDC2 (Sirp-α+CD1c+) subsets was a function of tissue site and was conserved between donors. We identified cDC2 as the major mature (HLA-DRhi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal site, reflecting their tissue-migratory origin. These distribution and maturation patterns were largely maintained throughout life, with site-specific variations. Our findings provide evidence for localized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2 functioning as guardians of the mucosa.
[Display omitted]
•Human cDC1 and cDC2 subset distribution is a function of tissue site•cDC2s exhibit maturation and migration phenotypes in mucosal-draining lymph nodes•Mature cDC2s accumulate in lymph node interfollicular zones•Localized cDC subset distribution and maturation is largely retained over life
Dendritic cells (DCs) function as tissue sentinels, but this role is difficult to study in humans. In this issue of Immunity, Granot et al. show through analysis of lymphoid and mucosal tissues that human DC maturation is tissue specific, associated with migration phenotypes, and predominantly observed among the cDC2 subset.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28329707</pmid><doi>10.1016/j.immuni.2017.02.019</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age composition Aged Aged, 80 and over Antigens Blood & organ donations CD1c antigen Cdc2 protein Cell adhesion & migration Child Child, Preschool Dendritic cells Dendritic Cells - cytology Division of labor Female Flow Cytometry Fluorescent Antibody Technique Histocompatibility antigen HLA Homeostasis human immunology Humans Infant Intestine Lungs Lymph nodes Lymphatic system Lymphocytes Male Maturation Middle Aged Mucosa mucosal immunity Organ donors Rodents T cell receptors tissue immunity Tissues Young Adult |
| title | Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life |
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