Regulation of Human Growth Hormone Receptor Expression by MicroRNAs

Human GH binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation, and metabolism. GHR deficiency is associated with growth and metabolic disorders whereas increased GHR expression has been reported in certain c...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2014-09, Vol.28 (9), p.1448-1459
Hauptverfasser:	Elzein, Samar, Goodyer, Cynthia Gates
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Binding Sites Cell Differentiation Cell Line Cell Line, Tumor Cloning, Molecular Gene Expression Regulation Gene Expression Regulation, Neoplastic HEK293 Cells Humans MCF-7 Cells Membrane Proteins - metabolism MicroRNAs - metabolism Mutagenesis Original Research Polymerase Chain Reaction RNA, Messenger - metabolism
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