Sphingosine Kinase 1 Isoform-Specific Interactions in Breast Cancer

Sphingosine kinase 1 (SK1) is a signaling enzyme that catalyzes the formation of sphingosine-1-phosphate. Overexpression of SK1 is causally associated with breast cancer progression and resistance to therapy. SK1 inhibitors are currently being investigated as promising breast cancer therapies. Two m...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2014-11, Vol.28 (11), p.1899-1915
Hauptverfasser:	Yagoub, Daniel, Wilkins, Marc R, Lay, Angelina J, Kaczorowski, Dominik C, Hatoum, Diana, Bajan, Sarah, Hutvagner, Gyorgy, Lai, Jack H, Wu, Wengen, Martiniello-Wilks, Rosetta, Xia, Pu, McGowan, Eileen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - metabolism Cell Adhesion - physiology Cell Line, Tumor Cell Movement - physiology Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism DNA-Binding Proteins - metabolism Female Humans Latent TGF-beta Binding Proteins - metabolism Lysophospholipids - metabolism MCF-7 Cells Original Research Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Isoforms - metabolism Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism
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