Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling

Diabetes is characterized by a loss and dysfunction of the β-cell. Glucagon-like peptide 1 receptor (GLP-1R) signaling plays an important role in β-cell survival and function. It is meaningful to identify promising agents from natural products which might activate GLP-1R signaling. In this study, pu...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2016-03, Vol.30 (3), p.361-371
Hauptverfasser:	Yang, Lei, Yao, Dongdong, Yang, Haiyuan, Wei, Yingjie, Peng, Yunru, Ding, Yongfang, Shu, Luan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Cytoprotection - drug effects Diabetes Mellitus, Experimental - pathology Diet, High-Fat Glucagon-Like Peptide 1 - metabolism Glucagon-Like Peptide-1 Receptor - metabolism Glucose - metabolism Hyperglycemia - complications Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Isoflavones - chemistry Isoflavones - pharmacology Lipid Metabolism - drug effects Mice, Inbred C57BL Mice, Obese Original Research Signal Transduction - drug effects Up-Regulation - drug effects
Online-Zugang:	Volltext
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