Radioactive Iodine Therapy and Glucose Tolerance
Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Exp...
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| Veröffentlicht in: | Cell journal (Yakhteh) 2017-07, Vol.19 (2), p.184-193 |
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| creator | Samadi, Roghaieh Shafiei, Babak Azizi, Fereidoun Ghasemi, Asghar |
| description | Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance. Overall, radioactive iodine uptake by the pancreas may damage beta-cells and predispose patients to glucose intolerance or type 2 diabetes, particularly in patients exposed to radioactive iodine therapy following total thyroidectomy. Further studies are needed to clarify and confirm this association. |
| doi_str_mv | 10.22074/cellj.2016.4251 |
| format | Article |
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The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance. Overall, radioactive iodine uptake by the pancreas may damage beta-cells and predispose patients to glucose intolerance or type 2 diabetes, particularly in patients exposed to radioactive iodine therapy following total thyroidectomy. Further studies are needed to clarify and confirm this association.</description><identifier>ISSN: 2228-5806</identifier><identifier>EISSN: 2228-5814</identifier><identifier>DOI: 10.22074/cellj.2016.4251</identifier><identifier>PMID: 28670511</identifier><language>eng</language><publisher>Iran: Royan Institute of Iran</publisher><subject>Beta cells ; Chromium ; Damage ; Diabetes mellitus (non-insulin dependent) ; Glucose ; Glucose tolerance ; Graves disease ; Intolerance ; Iodides ; Iodine ; Iodine radioisotopes ; Mortality ; Pancreas ; Papillary thyroid carcinoma ; Review ; Therapy ; Thyroid ; Thyroid cancer ; Thyroid gland ; Thyroidectomy</subject><ispartof>Cell journal (Yakhteh), 2017-07, Vol.19 (2), p.184-193</ispartof><rights>2017. This work is published under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413587/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413587/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28670511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samadi, Roghaieh</creatorcontrib><creatorcontrib>Shafiei, Babak</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><creatorcontrib>Ghasemi, Asghar</creatorcontrib><title>Radioactive Iodine Therapy and Glucose Tolerance</title><title>Cell journal (Yakhteh)</title><addtitle>Cell J</addtitle><description>Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance. Overall, radioactive iodine uptake by the pancreas may damage beta-cells and predispose patients to glucose intolerance or type 2 diabetes, particularly in patients exposed to radioactive iodine therapy following total thyroidectomy. Further studies are needed to clarify and confirm this association.</description><subject>Beta cells</subject><subject>Chromium</subject><subject>Damage</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Graves disease</subject><subject>Intolerance</subject><subject>Iodides</subject><subject>Iodine</subject><subject>Iodine radioisotopes</subject><subject>Mortality</subject><subject>Pancreas</subject><subject>Papillary thyroid carcinoma</subject><subject>Review</subject><subject>Therapy</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>Thyroidectomy</subject><issn>2228-5806</issn><issn>2228-5814</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkM1Lw0AQxRdRbKm9e5KAFy-pO7Mf2b0IIloLBUHqedlstjYlzcakKfS_d8Va1LnM8ObH480Qcgl0gkgzfut8Va0nSEFOOAo4IUNEVKlQwE-PM5UDMu66NY0lKYLGczJAJTMqAIaEvtqiDNZty51PZqEoa58sVr61zT6xdZFMq96FLmqhimLt_AU5W9qq8-NDH5G3p8fFw3M6f5nOHu7naYOab1PlC0BQaK0TKncKBNicMwU5c9wXmqFQWkoUAqXXIDlQri0rkFmeLZeejcjdt2_T5xtfOF9vW1uZpi03tt2bYEvzd1OXK_MedkZwYEJl0eDmYNCGj953W7Mpu6-X2dqHvjOgQYgIooro9T90Hfq2jucZVJxqTSMaqavfiY5Rfp7JPgHapHY7</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Samadi, Roghaieh</creator><creator>Shafiei, Babak</creator><creator>Azizi, Fereidoun</creator><creator>Ghasemi, Asghar</creator><general>Royan Institute of Iran</general><general>Royan Institute</general><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201707</creationdate><title>Radioactive Iodine Therapy and Glucose Tolerance</title><author>Samadi, Roghaieh ; Shafiei, Babak ; Azizi, Fereidoun ; Ghasemi, Asghar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p294t-8ed12182aac58bc8151ab4381b3c4ed9325896625526e91641049a3d23a47ffe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Beta cells</topic><topic>Chromium</topic><topic>Damage</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Graves disease</topic><topic>Intolerance</topic><topic>Iodides</topic><topic>Iodine</topic><topic>Iodine radioisotopes</topic><topic>Mortality</topic><topic>Pancreas</topic><topic>Papillary thyroid carcinoma</topic><topic>Review</topic><topic>Therapy</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samadi, Roghaieh</creatorcontrib><creatorcontrib>Shafiei, Babak</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><creatorcontrib>Ghasemi, Asghar</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell journal (Yakhteh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samadi, Roghaieh</au><au>Shafiei, Babak</au><au>Azizi, Fereidoun</au><au>Ghasemi, Asghar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioactive Iodine Therapy and Glucose Tolerance</atitle><jtitle>Cell journal (Yakhteh)</jtitle><addtitle>Cell J</addtitle><date>2017-07</date><risdate>2017</risdate><volume>19</volume><issue>2</issue><spage>184</spage><epage>193</epage><pages>184-193</pages><issn>2228-5806</issn><eissn>2228-5814</eissn><abstract>Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance. Overall, radioactive iodine uptake by the pancreas may damage beta-cells and predispose patients to glucose intolerance or type 2 diabetes, particularly in patients exposed to radioactive iodine therapy following total thyroidectomy. Further studies are needed to clarify and confirm this association.</abstract><cop>Iran</cop><pub>Royan Institute of Iran</pub><pmid>28670511</pmid><doi>10.22074/cellj.2016.4251</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Beta cells Chromium Damage Diabetes mellitus (non-insulin dependent) Glucose Glucose tolerance Graves disease Intolerance Iodides Iodine Iodine radioisotopes Mortality Pancreas Papillary thyroid carcinoma Review Therapy Thyroid Thyroid cancer Thyroid gland Thyroidectomy |
| title | Radioactive Iodine Therapy and Glucose Tolerance |
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