Local translation in neuronal compartments: how local is local?
Efficient neuronal function depends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as the localization of translational machinery, spatial sprea...
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| Veröffentlicht in: | EMBO reports 2017-05, Vol.18 (5), p.693-711 |
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| creator | Rangaraju, Vidhya tom Dieck, Susanne Schuman, Erin M |
| description | Efficient neuronal function depends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as the localization of translational machinery, spatial spread of the newly translated proteins, and their site of action are carried out in specialized neuronal subcompartments to result in a localized functional outcome. In this review, we focus on the various aspects of these local translation compartments such as size, biochemical and organelle composition, structural boundaries, and temporal dynamics. We also discuss the apparent absence of definitive components of translation in these local compartments and the emerging state‐of‐the‐art tools that could help dissecting these conundrums in greater detail in the future.
Graphical Abstract
Local protein synthesis is central for efficient neuronal function. This review discusses various aspects of local translation compartments such as size, biochemical and organelle composition, structural boundaries and temporal dynamics. |
| doi_str_mv | 10.15252/embr.201744045 |
| format | Article |
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Graphical Abstract
Local protein synthesis is central for efficient neuronal function. This review discusses various aspects of local translation compartments such as size, biochemical and organelle composition, structural boundaries and temporal dynamics.</description><identifier>ISSN: 1469-221X</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.15252/embr.201744045</identifier><identifier>PMID: 28404606</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biochemistry ; Compartments ; Dendrites - physiology ; EMBO27 ; EMBO32 ; local translation ; Localization ; Machinery and equipment ; nascent protein ; Neuromodulation ; Neuronal Plasticity ; Neurons ; Neurons - cytology ; Neurons - physiology ; Organelles - physiology ; plasticity ; Protein Biosynthesis ; Protein synthesis ; Proteins ; Proteome ; Proteomes ; Review ; Reviews ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; spatial spread ; Translation</subject><ispartof>EMBO reports, 2017-05, Vol.18 (5), p.693-711</ispartof><rights>The Author(s) 2017</rights><rights>2017 The Authors</rights><rights>2017 The Authors.</rights><rights>2017 EMBO</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5795-10644429d03b6b41d055cb821703bfa8dbc1321ecfc0e210ed10518d825c9b6e3</citedby><cites>FETCH-LOGICAL-c5795-10644429d03b6b41d055cb821703bfa8dbc1321ecfc0e210ed10518d825c9b6e3</cites><orcidid>0000-0002-6716-4312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412868/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412868/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,41096,42165,45550,45551,46384,46808,51551,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.15252/embr.201744045$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28404606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rangaraju, Vidhya</creatorcontrib><creatorcontrib>tom Dieck, Susanne</creatorcontrib><creatorcontrib>Schuman, Erin M</creatorcontrib><title>Local translation in neuronal compartments: how local is local?</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>Efficient neuronal function depends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as the localization of translational machinery, spatial spread of the newly translated proteins, and their site of action are carried out in specialized neuronal subcompartments to result in a localized functional outcome. In this review, we focus on the various aspects of these local translation compartments such as size, biochemical and organelle composition, structural boundaries, and temporal dynamics. We also discuss the apparent absence of definitive components of translation in these local compartments and the emerging state‐of‐the‐art tools that could help dissecting these conundrums in greater detail in the future.
Graphical Abstract
Local protein synthesis is central for efficient neuronal function. This review discusses various aspects of local translation compartments such as size, biochemical and organelle composition, structural boundaries and temporal dynamics.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Compartments</subject><subject>Dendrites - physiology</subject><subject>EMBO27</subject><subject>EMBO32</subject><subject>local translation</subject><subject>Localization</subject><subject>Machinery and equipment</subject><subject>nascent protein</subject><subject>Neuromodulation</subject><subject>Neuronal Plasticity</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Organelles - physiology</subject><subject>plasticity</subject><subject>Protein Biosynthesis</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Proteome</subject><subject>Proteomes</subject><subject>Review</subject><subject>Reviews</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>spatial spread</subject><subject>Translation</subject><issn>1469-221X</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFLHDEUxkOxVGt77q0M9OJl9b1MMsl4qFhRK6wUSgVvIZPJ6shMsiYzLv73Zp112QriKY-X3_fxJR8h3xD2kVNOD2xXhX0KKBgDxj-QHWRFOclRyK3VTCleb5PPMd4BAC-F_ES2qUx0AcUOOZp6o9usD9rFVveNd1njMmeH4F3aG9_Ndeg76_p4mN36RdY-800ch6Mv5ONMt9F-XZ275Ors9N_J78n0z_nFyfF0Yrgo-QShYIzRsoa8KiqGNXBuKklRpMVMy7oymFO0ZmbAUgRbI3CUtaTclFVh813yc_SdD1Vna5MCBd2qeWg6HR6V1436_8Y1t-rGPyjOkMpCJoO9lUHw94ONveqaaGzbamf9EBVKKVhOBYqE_niF3vkhpO9YUiUHCiBoog5GygQfY7CzdRgE9VyOWpaj1uUkxffNN6z5lzYScDgCi6a1j-_5qdPLX3833WEUx6RzNzZspH4j0BPI0atH</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Rangaraju, Vidhya</creator><creator>tom Dieck, Susanne</creator><creator>Schuman, Erin M</creator><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6716-4312</orcidid></search><sort><creationdate>201705</creationdate><title>Local translation in neuronal compartments: how local is local?</title><author>Rangaraju, Vidhya ; tom Dieck, Susanne ; Schuman, Erin M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5795-10644429d03b6b41d055cb821703bfa8dbc1321ecfc0e210ed10518d825c9b6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Compartments</topic><topic>Dendrites - physiology</topic><topic>EMBO27</topic><topic>EMBO32</topic><topic>local translation</topic><topic>Localization</topic><topic>Machinery and equipment</topic><topic>nascent protein</topic><topic>Neuromodulation</topic><topic>Neuronal Plasticity</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Organelles - physiology</topic><topic>plasticity</topic><topic>Protein Biosynthesis</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Proteome</topic><topic>Proteomes</topic><topic>Review</topic><topic>Reviews</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>spatial spread</topic><topic>Translation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rangaraju, Vidhya</creatorcontrib><creatorcontrib>tom Dieck, Susanne</creatorcontrib><creatorcontrib>Schuman, Erin M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rangaraju, Vidhya</au><au>tom Dieck, Susanne</au><au>Schuman, Erin M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local translation in neuronal compartments: how local is local?</atitle><jtitle>EMBO reports</jtitle><stitle>EMBO Rep</stitle><addtitle>EMBO Rep</addtitle><date>2017-05</date><risdate>2017</risdate><volume>18</volume><issue>5</issue><spage>693</spage><epage>711</epage><pages>693-711</pages><issn>1469-221X</issn><eissn>1469-3178</eissn><abstract>Efficient neuronal function depends on the continued modulation of the local neuronal proteome. 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Graphical Abstract
Local protein synthesis is central for efficient neuronal function. This review discusses various aspects of local translation compartments such as size, biochemical and organelle composition, structural boundaries and temporal dynamics.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28404606</pmid><doi>10.15252/embr.201744045</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-6716-4312</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry Compartments Dendrites - physiology EMBO27 EMBO32 local translation Localization Machinery and equipment nascent protein Neuromodulation Neuronal Plasticity Neurons Neurons - cytology Neurons - physiology Organelles - physiology plasticity Protein Biosynthesis Protein synthesis Proteins Proteome Proteomes Review Reviews RNA, Messenger - genetics RNA, Messenger - metabolism spatial spread Translation |
| title | Local translation in neuronal compartments: how local is local? |
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