Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis
In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) wer...
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| Veröffentlicht in: | International journal of molecular sciences 2017-04, Vol.18 (4), p.753-753 |
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| creator | Dumnicka, Paulina Kuśnierz-Cabala, Beata Sporek, Mateusz Mazur-Laskowska, Małgorzata Gil, Krzysztof Kuźniewski, Marek Ceranowicz, Piotr Warzecha, Zygmunt Dembiński, Artur Bonior, Joanna Drożdż, Ryszard |
| description | In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy. Sixty-nine adult patients with AP were recruited: five with SAP, 15 with moderately severe AP (MSAP) and 49 with mild AP. Six patients were diagnosed with DIC according to International Society on Thrombosis and Haemostasis (ISTH) score. All patients had at least one abnormal result of routine tests of hemostasis (low platelet count, prolonged clotting times, decreased fibrinogen, and increased D-dimer). The severity of coagulopathy correlated with AP severity according to 2012 Atlanta criteria, bedside index of severity in AP and duration of hospital stay. D-dimers correlated independently with C-reactive protein and studied markers of endothelial dysfunction. Angiopoietin-2, D-dimer, and ISTH score were best predictors of SAP, while sFlt-1 was good predictor of MSAP plus SAP. In clinical practice, routine tests of hemostasis may assist prognosis of AP. |
| doi_str_mv | 10.3390/ijms18040753 |
| format | Article |
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Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy. Sixty-nine adult patients with AP were recruited: five with SAP, 15 with moderately severe AP (MSAP) and 49 with mild AP. Six patients were diagnosed with DIC according to International Society on Thrombosis and Haemostasis (ISTH) score. All patients had at least one abnormal result of routine tests of hemostasis (low platelet count, prolonged clotting times, decreased fibrinogen, and increased D-dimer). The severity of coagulopathy correlated with AP severity according to 2012 Atlanta criteria, bedside index of severity in AP and duration of hospital stay. D-dimers correlated independently with C-reactive protein and studied markers of endothelial dysfunction. Angiopoietin-2, D-dimer, and ISTH score were best predictors of SAP, while sFlt-1 was good predictor of MSAP plus SAP. In clinical practice, routine tests of hemostasis may assist prognosis of AP.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms18040753</identifier><identifier>PMID: 28368336</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abnormalities ; Acute Disease ; Aged ; Aged, 80 and over ; Angiopoietin ; Angiopoietin-2 - blood ; Biomarkers - blood ; Blood Coagulation Disorders - blood ; Blood Coagulation Disorders - complications ; Blood Coagulation Disorders - diagnosis ; C-reactive protein ; C-Reactive Protein - metabolism ; Clotting ; Coagulation ; Disseminated intravascular coagulation ; Female ; Fibrin Fibrinogen Degradation Products - metabolism ; Fibrinogen ; Hemostasis ; Hemostatics ; Humans ; Inflammation ; Kinases ; Logistic Models ; Male ; Markers ; Middle Aged ; Pancreas ; Pancreatitis ; Pancreatitis - complications ; Patients ; Prognosis ; Prospective Studies ; Protein-tyrosine kinase ; SAP protein ; Severity of Illness Index ; Solubility ; Thrombosis ; Tyrosine ; Vascular Endothelial Growth Factor Receptor-1 - blood</subject><ispartof>International journal of molecular sciences, 2017-04, Vol.18 (4), p.753-753</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-5c36d94ecea6f4efda0c9daefb76b0b900b208168f8bf9faa58ac5fe2ad14ff3</citedby><cites>FETCH-LOGICAL-c445t-5c36d94ecea6f4efda0c9daefb76b0b900b208168f8bf9faa58ac5fe2ad14ff3</cites><orcidid>0000-0003-4436-9080 ; 0000-0002-4732-7698 ; 0000-0003-3478-0108 ; 0000-0002-0494-6528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412338/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412338/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28368336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dumnicka, Paulina</creatorcontrib><creatorcontrib>Kuśnierz-Cabala, Beata</creatorcontrib><creatorcontrib>Sporek, Mateusz</creatorcontrib><creatorcontrib>Mazur-Laskowska, Małgorzata</creatorcontrib><creatorcontrib>Gil, Krzysztof</creatorcontrib><creatorcontrib>Kuźniewski, Marek</creatorcontrib><creatorcontrib>Ceranowicz, Piotr</creatorcontrib><creatorcontrib>Warzecha, Zygmunt</creatorcontrib><creatorcontrib>Dembiński, Artur</creatorcontrib><creatorcontrib>Bonior, Joanna</creatorcontrib><creatorcontrib>Drożdż, Ryszard</creatorcontrib><title>Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy. Sixty-nine adult patients with AP were recruited: five with SAP, 15 with moderately severe AP (MSAP) and 49 with mild AP. Six patients were diagnosed with DIC according to International Society on Thrombosis and Haemostasis (ISTH) score. All patients had at least one abnormal result of routine tests of hemostasis (low platelet count, prolonged clotting times, decreased fibrinogen, and increased D-dimer). The severity of coagulopathy correlated with AP severity according to 2012 Atlanta criteria, bedside index of severity in AP and duration of hospital stay. D-dimers correlated independently with C-reactive protein and studied markers of endothelial dysfunction. Angiopoietin-2, D-dimer, and ISTH score were best predictors of SAP, while sFlt-1 was good predictor of MSAP plus SAP. In clinical practice, routine tests of hemostasis may assist prognosis of AP.</description><subject>Abnormalities</subject><subject>Acute Disease</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiopoietin</subject><subject>Angiopoietin-2 - blood</subject><subject>Biomarkers - blood</subject><subject>Blood Coagulation Disorders - blood</subject><subject>Blood Coagulation Disorders - complications</subject><subject>Blood Coagulation Disorders - diagnosis</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Clotting</subject><subject>Coagulation</subject><subject>Disseminated intravascular coagulation</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>Fibrinogen</subject><subject>Hemostasis</subject><subject>Hemostatics</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Markers</subject><subject>Middle Aged</subject><subject>Pancreas</subject><subject>Pancreatitis</subject><subject>Pancreatitis - complications</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Protein-tyrosine kinase</subject><subject>SAP protein</subject><subject>Severity of Illness Index</subject><subject>Solubility</subject><subject>Thrombosis</subject><subject>Tyrosine</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkktv1DAUhSMEog_YsUaW2LQSAb-S2BukaEQBdSSQOvvIca5nPCT2YDug-TP8VtxOqQY2Xdny_XTOvdenKF4R_I4xid_b7RSJwBw3FXtSnBJOaYlx3Tw9up8UZzFuMaaMVvJ5cUIFqwVj9Wnx-wbCPKGFdxpcCipZ7yLyBrVubf3OW0jWlRQpN6AbP879CMhMsVza74BW--CjdYCurVMREEEX8WpMJblEbQDUxui1VQkG9MumTTZR63n0O5U2e6Qm79boWzbMvvEAtHpOkN-cDpALycYXxTOjxggv78_zYnX1cbX4XC6_fvqyaJel5rxKZaVZPUgOGlRtOJhBYS0HBaZv6h73EuOeYkFqYURvpFGqEkpXBqgaCDeGnRcfDrK7uZ9gOKxi7HbBTirsO69s92_F2U239j-7ihPKmMgCF_cCwf-YIaZuslHDOCoHfo4dkZg0lWyIfBwVggnOCGEZffMfuvVzcHkRmZKykby-E3x7oHT-jRjAPPRNcHcbke44Ihl_fTzrA_w3E-wPLC-7FA</recordid><startdate>20170402</startdate><enddate>20170402</enddate><creator>Dumnicka, Paulina</creator><creator>Kuśnierz-Cabala, Beata</creator><creator>Sporek, Mateusz</creator><creator>Mazur-Laskowska, Małgorzata</creator><creator>Gil, Krzysztof</creator><creator>Kuźniewski, Marek</creator><creator>Ceranowicz, Piotr</creator><creator>Warzecha, Zygmunt</creator><creator>Dembiński, Artur</creator><creator>Bonior, Joanna</creator><creator>Drożdż, Ryszard</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4436-9080</orcidid><orcidid>https://orcid.org/0000-0002-4732-7698</orcidid><orcidid>https://orcid.org/0000-0003-3478-0108</orcidid><orcidid>https://orcid.org/0000-0002-0494-6528</orcidid></search><sort><creationdate>20170402</creationdate><title>Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis</title><author>Dumnicka, Paulina ; Kuśnierz-Cabala, Beata ; Sporek, Mateusz ; Mazur-Laskowska, Małgorzata ; Gil, Krzysztof ; Kuźniewski, Marek ; Ceranowicz, Piotr ; Warzecha, Zygmunt ; Dembiński, Artur ; Bonior, Joanna ; Drożdż, Ryszard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-5c36d94ecea6f4efda0c9daefb76b0b900b208168f8bf9faa58ac5fe2ad14ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abnormalities</topic><topic>Acute Disease</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiopoietin</topic><topic>Angiopoietin-2 - blood</topic><topic>Biomarkers - blood</topic><topic>Blood Coagulation Disorders - blood</topic><topic>Blood Coagulation Disorders - complications</topic><topic>Blood Coagulation Disorders - diagnosis</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Clotting</topic><topic>Coagulation</topic><topic>Disseminated intravascular coagulation</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Fibrinogen</topic><topic>Hemostasis</topic><topic>Hemostatics</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Kinases</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Markers</topic><topic>Middle Aged</topic><topic>Pancreas</topic><topic>Pancreatitis</topic><topic>Pancreatitis - complications</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Protein-tyrosine kinase</topic><topic>SAP protein</topic><topic>Severity of Illness Index</topic><topic>Solubility</topic><topic>Thrombosis</topic><topic>Tyrosine</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dumnicka, Paulina</creatorcontrib><creatorcontrib>Kuśnierz-Cabala, Beata</creatorcontrib><creatorcontrib>Sporek, Mateusz</creatorcontrib><creatorcontrib>Mazur-Laskowska, Małgorzata</creatorcontrib><creatorcontrib>Gil, Krzysztof</creatorcontrib><creatorcontrib>Kuźniewski, Marek</creatorcontrib><creatorcontrib>Ceranowicz, Piotr</creatorcontrib><creatorcontrib>Warzecha, Zygmunt</creatorcontrib><creatorcontrib>Dembiński, Artur</creatorcontrib><creatorcontrib>Bonior, Joanna</creatorcontrib><creatorcontrib>Drożdż, Ryszard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dumnicka, Paulina</au><au>Kuśnierz-Cabala, Beata</au><au>Sporek, Mateusz</au><au>Mazur-Laskowska, Małgorzata</au><au>Gil, Krzysztof</au><au>Kuźniewski, Marek</au><au>Ceranowicz, Piotr</au><au>Warzecha, Zygmunt</au><au>Dembiński, Artur</au><au>Bonior, Joanna</au><au>Drożdż, Ryszard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2017-04-02</date><risdate>2017</risdate><volume>18</volume><issue>4</issue><spage>753</spage><epage>753</epage><pages>753-753</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy. Sixty-nine adult patients with AP were recruited: five with SAP, 15 with moderately severe AP (MSAP) and 49 with mild AP. Six patients were diagnosed with DIC according to International Society on Thrombosis and Haemostasis (ISTH) score. All patients had at least one abnormal result of routine tests of hemostasis (low platelet count, prolonged clotting times, decreased fibrinogen, and increased D-dimer). The severity of coagulopathy correlated with AP severity according to 2012 Atlanta criteria, bedside index of severity in AP and duration of hospital stay. D-dimers correlated independently with C-reactive protein and studied markers of endothelial dysfunction. Angiopoietin-2, D-dimer, and ISTH score were best predictors of SAP, while sFlt-1 was good predictor of MSAP plus SAP. In clinical practice, routine tests of hemostasis may assist prognosis of AP.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28368336</pmid><doi>10.3390/ijms18040753</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4436-9080</orcidid><orcidid>https://orcid.org/0000-0002-4732-7698</orcidid><orcidid>https://orcid.org/0000-0003-3478-0108</orcidid><orcidid>https://orcid.org/0000-0002-0494-6528</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2017-04, Vol.18 (4), p.753-753 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Abnormalities Acute Disease Aged Aged, 80 and over Angiopoietin Angiopoietin-2 - blood Biomarkers - blood Blood Coagulation Disorders - blood Blood Coagulation Disorders - complications Blood Coagulation Disorders - diagnosis C-reactive protein C-Reactive Protein - metabolism Clotting Coagulation Disseminated intravascular coagulation Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinogen Hemostasis Hemostatics Humans Inflammation Kinases Logistic Models Male Markers Middle Aged Pancreas Pancreatitis Pancreatitis - complications Patients Prognosis Prospective Studies Protein-tyrosine kinase SAP protein Severity of Illness Index Solubility Thrombosis Tyrosine Vascular Endothelial Growth Factor Receptor-1 - blood |
| title | Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis |
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