IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT
The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects. The leaves of contain several active ingredient compounds such as rebaudioside. extract have been used for many purposes. Active oxygen radicals can induce base modifications, DNA...
Gespeichert in:
| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2016-01, Vol.13 (6), p.18-21 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21 |
|---|---|
| container_issue | 6 |
| container_start_page | 18 |
| container_title | African journal of traditional, complementary, and alternative medicines |
| container_volume | 13 |
| creator | Moselhy, Said S Ghoneim, Magdy A Khan, Jehan A |
| description | The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects. The leaves of
contain several active ingredient compounds such as rebaudioside.
extract have been used for many purposes. Active oxygen radicals can induce base modifications, DNA breakage, and intracellular protein crosslink's. This study was done to evaluate the potential of
extract as antibacterial and antioxidants actions.
Antibacterial activity of different extracts of
was tested in vitro against different species of bacteria and hepato-protective efficacy was testes in rats injected with CCl
as hepatotoxic.
Acetone extract exhibited antibacterial activity against selected five bacteria species. The acetone extract suppressed the elevation of serum ALT (p |
| doi_str_mv | 10.21010/ajtcam.v13i6.4 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5412192</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>28480355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-8742c56b2ddeb684563063610fd1915f4f3f2b07999a1dba6cb512953895c3183</originalsourceid><addsrcrecordid>eNpVUMtOwkAUnRiNILp2Z_oDhbnzYroxqaXoJJUxODQsTCZ9KgSEtEji31uLEl2dnHseNzkIXQPuE8CAB8lylyXr_h7oQvTZCeoSjrmLMWOnqItBeq7AIDrooq6XGFMJZHiOOkQyiSnnXfSiJk6szFQ7_mTktCTWThj70cw3Sk8cPW4Uox5VMNV3yo9a3_dFz9WoQedJm7ChjdJYn00YK98J52bqB-YSnZXJqi6ufrCHZuPQBA9upO9V4EduxkDuXDlkJOMiJXlepEIyLigWVAAuc_CAl6ykJUnx0PO8BPI0EVnKgXicSo9nFCTtodtD7_YjXRd5VrzvqmRlt9VinVSfdpMs7H_lffFmXzd7yxkQ8EhTMDgUZNWmrquiPGYB23ZoexjatkNb1iRu_r48-n-XpV8o53PS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT</title><source>MEDLINE</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Moselhy, Said S ; Ghoneim, Magdy A ; Khan, Jehan A</creator><creatorcontrib>Moselhy, Said S ; Ghoneim, Magdy A ; Khan, Jehan A</creatorcontrib><description>The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects. The leaves of
contain several active ingredient compounds such as rebaudioside.
extract have been used for many purposes. Active oxygen radicals can induce base modifications, DNA breakage, and intracellular protein crosslink's. This study was done to evaluate the potential of
extract as antibacterial and antioxidants actions.
Antibacterial activity of different extracts of
was tested in vitro against different species of bacteria and hepato-protective efficacy was testes in rats injected with CCl
as hepatotoxic.
Acetone extract exhibited antibacterial activity against selected five bacteria species. The acetone extract suppressed the elevation of serum ALT (p <0.05) and AST (p <0.001) activities induced by CCl
. Animals given stevia extract showed prevention against deleterious effects of CCl
by lowering lipid peroxidation and enhancement of antioxidant activities as SOD and CAT. The protection trial is better than treatment trial. Total phenolic content of aqueous and acetone extracts were found 30 mg and 85 mg gallic /gm extract respectively. While the total flavonoids were 40 mg and 80 mg quercetin/g respectively. The GC-MS analysis showed that monoterpene and indole are the main components. Aqueous extract don't show any antibacterial activity against the tested strains. The antioxidant properties were attributable to its phenolic content to scavenge free radicals.
Acetone extract possess a potent antimicrobial and activity against deleterious effect of CCl
-caused liver damage.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 2505-0044</identifier><identifier>DOI: 10.21010/ajtcam.v13i6.4</identifier><identifier>PMID: 28480355</identifier><language>eng</language><publisher>Nigeria: African Traditional Herbal Medicine Supporters Initiative (ATHMSI)</publisher><subject>Acetone - pharmacology ; Alanine Transaminase - blood ; Animals ; Anti-Infective Agents - pharmacology ; Antioxidants - pharmacology ; Aspartate Aminotransferases - blood ; Carbon Tetrachloride Poisoning - blood ; Carbon Tetrachloride Poisoning - drug therapy ; Carbon Tetrachloride Poisoning - etiology ; Catalase - drug effects ; Flavonoids - analysis ; Free Radical Scavengers - pharmacology ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Male ; Phenols - analysis ; Phytotherapy - methods ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Rats ; Stevia - chemistry ; Superoxide Dismutase - drug effects</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2016-01, Vol.13 (6), p.18-21</ispartof><rights>Copyright: © 2016 Afr. J. Traditional Complementary and Alternative Medicines 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-8742c56b2ddeb684563063610fd1915f4f3f2b07999a1dba6cb512953895c3183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412192/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412192/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28480355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moselhy, Said S</creatorcontrib><creatorcontrib>Ghoneim, Magdy A</creatorcontrib><creatorcontrib>Khan, Jehan A</creatorcontrib><title>IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT</title><title>African journal of traditional, complementary, and alternative medicines</title><addtitle>Afr J Tradit Complement Altern Med</addtitle><description>The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects. The leaves of
contain several active ingredient compounds such as rebaudioside.
extract have been used for many purposes. Active oxygen radicals can induce base modifications, DNA breakage, and intracellular protein crosslink's. This study was done to evaluate the potential of
extract as antibacterial and antioxidants actions.
Antibacterial activity of different extracts of
was tested in vitro against different species of bacteria and hepato-protective efficacy was testes in rats injected with CCl
as hepatotoxic.
Acetone extract exhibited antibacterial activity against selected five bacteria species. The acetone extract suppressed the elevation of serum ALT (p <0.05) and AST (p <0.001) activities induced by CCl
. Animals given stevia extract showed prevention against deleterious effects of CCl
by lowering lipid peroxidation and enhancement of antioxidant activities as SOD and CAT. The protection trial is better than treatment trial. Total phenolic content of aqueous and acetone extracts were found 30 mg and 85 mg gallic /gm extract respectively. While the total flavonoids were 40 mg and 80 mg quercetin/g respectively. The GC-MS analysis showed that monoterpene and indole are the main components. Aqueous extract don't show any antibacterial activity against the tested strains. The antioxidant properties were attributable to its phenolic content to scavenge free radicals.
Acetone extract possess a potent antimicrobial and activity against deleterious effect of CCl
-caused liver damage.</description><subject>Acetone - pharmacology</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Carbon Tetrachloride Poisoning - blood</subject><subject>Carbon Tetrachloride Poisoning - drug therapy</subject><subject>Carbon Tetrachloride Poisoning - etiology</subject><subject>Catalase - drug effects</subject><subject>Flavonoids - analysis</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Phenols - analysis</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Rats</subject><subject>Stevia - chemistry</subject><subject>Superoxide Dismutase - drug effects</subject><issn>0189-6016</issn><issn>2505-0044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUMtOwkAUnRiNILp2Z_oDhbnzYroxqaXoJJUxODQsTCZ9KgSEtEji31uLEl2dnHseNzkIXQPuE8CAB8lylyXr_h7oQvTZCeoSjrmLMWOnqItBeq7AIDrooq6XGFMJZHiOOkQyiSnnXfSiJk6szFQ7_mTktCTWThj70cw3Sk8cPW4Uox5VMNV3yo9a3_dFz9WoQedJm7ChjdJYn00YK98J52bqB-YSnZXJqi6ufrCHZuPQBA9upO9V4EduxkDuXDlkJOMiJXlepEIyLigWVAAuc_CAl6ykJUnx0PO8BPI0EVnKgXicSo9nFCTtodtD7_YjXRd5VrzvqmRlt9VinVSfdpMs7H_lffFmXzd7yxkQ8EhTMDgUZNWmrquiPGYB23ZoexjatkNb1iRu_r48-n-XpV8o53PS</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Moselhy, Said S</creator><creator>Ghoneim, Magdy A</creator><creator>Khan, Jehan A</creator><general>African Traditional Herbal Medicine Supporters Initiative (ATHMSI)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT</title><author>Moselhy, Said S ; Ghoneim, Magdy A ; Khan, Jehan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-8742c56b2ddeb684563063610fd1915f4f3f2b07999a1dba6cb512953895c3183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetone - pharmacology</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Carbon Tetrachloride Poisoning - blood</topic><topic>Carbon Tetrachloride Poisoning - drug therapy</topic><topic>Carbon Tetrachloride Poisoning - etiology</topic><topic>Catalase - drug effects</topic><topic>Flavonoids - analysis</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Phenols - analysis</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Rats</topic><topic>Stevia - chemistry</topic><topic>Superoxide Dismutase - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moselhy, Said S</creatorcontrib><creatorcontrib>Ghoneim, Magdy A</creatorcontrib><creatorcontrib>Khan, Jehan A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moselhy, Said S</au><au>Ghoneim, Magdy A</au><au>Khan, Jehan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><addtitle>Afr J Tradit Complement Altern Med</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>13</volume><issue>6</issue><spage>18</spage><epage>21</epage><pages>18-21</pages><issn>0189-6016</issn><eissn>2505-0044</eissn><abstract>The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects. The leaves of
contain several active ingredient compounds such as rebaudioside.
extract have been used for many purposes. Active oxygen radicals can induce base modifications, DNA breakage, and intracellular protein crosslink's. This study was done to evaluate the potential of
extract as antibacterial and antioxidants actions.
Antibacterial activity of different extracts of
was tested in vitro against different species of bacteria and hepato-protective efficacy was testes in rats injected with CCl
as hepatotoxic.
Acetone extract exhibited antibacterial activity against selected five bacteria species. The acetone extract suppressed the elevation of serum ALT (p <0.05) and AST (p <0.001) activities induced by CCl
. Animals given stevia extract showed prevention against deleterious effects of CCl
by lowering lipid peroxidation and enhancement of antioxidant activities as SOD and CAT. The protection trial is better than treatment trial. Total phenolic content of aqueous and acetone extracts were found 30 mg and 85 mg gallic /gm extract respectively. While the total flavonoids were 40 mg and 80 mg quercetin/g respectively. The GC-MS analysis showed that monoterpene and indole are the main components. Aqueous extract don't show any antibacterial activity against the tested strains. The antioxidant properties were attributable to its phenolic content to scavenge free radicals.
Acetone extract possess a potent antimicrobial and activity against deleterious effect of CCl
-caused liver damage.</abstract><cop>Nigeria</cop><pub>African Traditional Herbal Medicine Supporters Initiative (ATHMSI)</pub><pmid>28480355</pmid><doi>10.21010/ajtcam.v13i6.4</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0189-6016 |
| ispartof | African journal of traditional, complementary, and alternative medicines, 2016-01, Vol.13 (6), p.18-21 |
| issn | 0189-6016 2505-0044 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5412192 |
| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acetone - pharmacology Alanine Transaminase - blood Animals Anti-Infective Agents - pharmacology Antioxidants - pharmacology Aspartate Aminotransferases - blood Carbon Tetrachloride Poisoning - blood Carbon Tetrachloride Poisoning - drug therapy Carbon Tetrachloride Poisoning - etiology Catalase - drug effects Flavonoids - analysis Free Radical Scavengers - pharmacology Lipid Peroxidation - drug effects Liver - drug effects Male Phenols - analysis Phytotherapy - methods Plant Extracts - pharmacology Plant Leaves - chemistry Rats Stevia - chemistry Superoxide Dismutase - drug effects |
| title | IN VITRO AND IN VIVO EVALUATION OF ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL OF STEVIA EXTRACT |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T20%3A34%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IN%20VITRO%20AND%20IN%20VIVO%20EVALUATION%20OF%20ANTIMICROBIAL%20AND%20ANTIOXIDANT%20POTENTIAL%20OF%20STEVIA%20EXTRACT&rft.jtitle=African%20journal%20of%20traditional,%20complementary,%20and%20alternative%20medicines&rft.au=Moselhy,%20Said%20S&rft.date=2016-01-01&rft.volume=13&rft.issue=6&rft.spage=18&rft.epage=21&rft.pages=18-21&rft.issn=0189-6016&rft.eissn=2505-0044&rft_id=info:doi/10.21010/ajtcam.v13i6.4&rft_dat=%3Cpubmed_cross%3E28480355%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/28480355&rfr_iscdi=true |