CpG in Combination with an Inhibitor of Notch Signaling Suppresses Formalin-Inactivated Respiratory Syncytial Virus-Enhanced Airway Hyperresponsiveness and Inflammation by Inhibiting Th17 Memory Responses and Promoting Tissue-Resident Memory Cells in Lungs

Respiratory syncytial virus (RSV) is the leading cause of childhood hospitalizations. The formalin-inactivated RSV (FI-RSV) vaccine-enhanced respiratory disease (ERD) has been an obstacle to the development of a safe and effective killed RSV vaccine. Agonists of Toll-like receptor (TLR) have been sh...

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Veröffentlicht in:	Journal of virology 2017-05, Vol.91 (10)
Hauptverfasser:	Zhang, Lei, Li, Hongyong, Hai, Yan, Yin, Wei, Li, Wenjian, Zheng, Boyang, Du, Xiaomin, Li, Na, Zhang, Zhengzheng, Deng, Yuqing, Zeng, Ruihong, Wei, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry Animals Bronchial Hyperreactivity - chemically induced Carbamates - pharmacology CD8-Positive T-Lymphocytes - immunology Dipeptides - pharmacology Formaldehyde Humans Immunologic Memory Inflammation Lung - immunology Lung - virology Mice Mice, Inbred BALB C Oligodeoxyribonucleotides - pharmacology Receptors, Notch - metabolism Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - immunology Signal Transduction Th17 Cells - immunology Toll-Like Receptor 1 - immunology Toll-Like Receptor 1 - metabolism Vaccines and Antiviral Agents Vaccines, Inactivated - adverse effects Vaccines, Inactivated - immunology
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