Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases
Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hemat...
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| Veröffentlicht in: | Internal Medicine 2017/03/15, Vol.56(6), pp.707-711 |
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| creator | Ino, Kazuko Nakase, Kazunori Nakamura, Akiko Nakamori, Yoshiki Sugawara, Yumiko Miyazaki, Kana Monma, Fumihiko Fujieda, Atsushi Sugimoto, Yuka Ohishi, Kohshi Masuya, Masahiro Katayama, Naoyuki |
| description | Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B. In this report, a PCR analysis proved very useful for managing PM in patients with hematologic malignancies. |
| doi_str_mv | 10.2169/internalmedicine.56.7647 |
| format | Article |
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We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B. In this report, a PCR analysis proved very useful for managing PM in patients with hematologic malignancies.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.56.7647</identifier><identifier>PMID: 28321075</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Absidia ; Adult ; Aged ; Amphotericin B ; Amphotericin B - therapeutic use ; Antifungal Agents - therapeutic use ; Case Report ; Cunninghamella ; Female ; Fungi ; hematologic malignancy ; Hematologic Neoplasms - complications ; Humans ; Internal medicine ; Lung Diseases, Fungal - complications ; Lung Diseases, Fungal - diagnosis ; Lung Diseases, Fungal - drug therapy ; Male ; Middle Aged ; Mucormycosis ; Mucormycosis - complications ; Mucormycosis - diagnosis ; Mucormycosis - drug therapy ; Peripheral blood ; Polymerase Chain Reaction ; pulmonary mucormycosis ; Rhizopus</subject><ispartof>Internal Medicine, 2017/03/15, Vol.56(6), pp.707-711</ispartof><rights>2017 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c642t-4732a4fab1e17b4d79be790fd4dff621c77619cba11ec2ac17b2e5475db1e6b13</citedby><cites>FETCH-LOGICAL-c642t-4732a4fab1e17b4d79be790fd4dff621c77619cba11ec2ac17b2e5475db1e6b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410485/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410485/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1881,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28321075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ino, Kazuko</creatorcontrib><creatorcontrib>Nakase, Kazunori</creatorcontrib><creatorcontrib>Nakamura, Akiko</creatorcontrib><creatorcontrib>Nakamori, Yoshiki</creatorcontrib><creatorcontrib>Sugawara, Yumiko</creatorcontrib><creatorcontrib>Miyazaki, Kana</creatorcontrib><creatorcontrib>Monma, Fumihiko</creatorcontrib><creatorcontrib>Fujieda, Atsushi</creatorcontrib><creatorcontrib>Sugimoto, Yuka</creatorcontrib><creatorcontrib>Ohishi, Kohshi</creatorcontrib><creatorcontrib>Masuya, Masahiro</creatorcontrib><creatorcontrib>Katayama, Naoyuki</creatorcontrib><title>Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B. 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Nakase, Kazunori ; Nakamura, Akiko ; Nakamori, Yoshiki ; Sugawara, Yumiko ; Miyazaki, Kana ; Monma, Fumihiko ; Fujieda, Atsushi ; Sugimoto, Yuka ; Ohishi, Kohshi ; Masuya, Masahiro ; Katayama, Naoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-4732a4fab1e17b4d79be790fd4dff621c77619cba11ec2ac17b2e5475db1e6b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absidia</topic><topic>Adult</topic><topic>Aged</topic><topic>Amphotericin B</topic><topic>Amphotericin B - therapeutic use</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Case Report</topic><topic>Cunninghamella</topic><topic>Female</topic><topic>Fungi</topic><topic>hematologic malignancy</topic><topic>Hematologic Neoplasms - complications</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Lung Diseases, Fungal - complications</topic><topic>Lung Diseases, Fungal - diagnosis</topic><topic>Lung Diseases, Fungal - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucormycosis</topic><topic>Mucormycosis - complications</topic><topic>Mucormycosis - diagnosis</topic><topic>Mucormycosis - drug therapy</topic><topic>Peripheral blood</topic><topic>Polymerase Chain Reaction</topic><topic>pulmonary mucormycosis</topic><topic>Rhizopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ino, Kazuko</creatorcontrib><creatorcontrib>Nakase, Kazunori</creatorcontrib><creatorcontrib>Nakamura, Akiko</creatorcontrib><creatorcontrib>Nakamori, Yoshiki</creatorcontrib><creatorcontrib>Sugawara, Yumiko</creatorcontrib><creatorcontrib>Miyazaki, Kana</creatorcontrib><creatorcontrib>Monma, Fumihiko</creatorcontrib><creatorcontrib>Fujieda, Atsushi</creatorcontrib><creatorcontrib>Sugimoto, Yuka</creatorcontrib><creatorcontrib>Ohishi, Kohshi</creatorcontrib><creatorcontrib>Masuya, Masahiro</creatorcontrib><creatorcontrib>Katayama, Naoyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ino, Kazuko</au><au>Nakase, Kazunori</au><au>Nakamura, Akiko</au><au>Nakamori, Yoshiki</au><au>Sugawara, Yumiko</au><au>Miyazaki, Kana</au><au>Monma, Fumihiko</au><au>Fujieda, Atsushi</au><au>Sugimoto, Yuka</au><au>Ohishi, Kohshi</au><au>Masuya, Masahiro</au><au>Katayama, Naoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| ispartof | Internal Medicine, 2017/03/15, Vol.56(6), pp.707-711 |
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| source | MEDLINE; PubMed Central; J-STAGE; PubMed Central Open Access |
| subjects | Absidia Adult Aged Amphotericin B Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Case Report Cunninghamella Female Fungi hematologic malignancy Hematologic Neoplasms - complications Humans Internal medicine Lung Diseases, Fungal - complications Lung Diseases, Fungal - diagnosis Lung Diseases, Fungal - drug therapy Male Middle Aged Mucormycosis Mucormycosis - complications Mucormycosis - diagnosis Mucormycosis - drug therapy Peripheral blood Polymerase Chain Reaction pulmonary mucormycosis Rhizopus |
| title | Management of Pulmonary Mucormycosis Based on a Polymerase Chain Reaction (PCR) Diagnosis in Patients with Hematologic Malignancies: A Report of Four Cases |
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