A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel

Notch signaling pathway is an embryonic program that becomes reactivated in pancreatic cancer and contributes to cancer stem cell (CSC) maintenance. We explored the concept of oncolytic adenoviral activity in response to Notch activation signaling, in the context of a chimeric promoter with uPAR reg...

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Veröffentlicht in:	Oncotarget 2017-04, Vol.8 (14), p.22700-22715
Hauptverfasser:	Mato-Berciano, Ana, Raimondi, Giulia, Maliandi, Maria Victoria, Alemany, Ramon, Montoliu, Lluis, Fillat, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Albumins - administration & dosage Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Biomarkers, Tumor - metabolism Cell Proliferation - drug effects Combined Modality Therapy Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Drug Synergism Humans Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Neoplastic Stem Cells - virology Oncolytic Virotherapy Paclitaxel - administration & dosage Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Pancreatic Neoplasms - virology Receptors, Notch - metabolism Receptors, Urokinase Plasminogen Activator - metabolism Research Paper Tumor Cells, Cultured Xenograft Model Antitumor Assays
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