A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma

Tumors are capable of coopting hematopoietic cells to create a suitable microenvironment to support malignant growth. Here, we have demonstrated that upregulation of kinase insert domain receptor (KDR), also known as VEGFR2, in a myeloid cell sublineage is necessary for malignant progression of glio...

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Veröffentlicht in:	The Journal of clinical investigation 2017-05, Vol.127 (5), p.1826-1838
Hauptverfasser:	Huang, Yujie, Rajappa, Prajwal, Hu, Wenhuo, Hoffman, Caitlin, Cisse, Babacar, Kim, Joon-Hyung, Gorge, Emilie, Yanowitch, Rachel, Cope, William, Vartanian, Emma, Xu, Raymond, Zhang, Tuo, Pisapia, David, Xiang, Jenny, Huse, Jason, Matei, Irina, Peinado, Hector, Bromberg, Jacqueline, Holland, Eric, Ding, Bi-Sen, Rafii, Shahin, Lyden, David, Greenfield, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cell Line, Tumor Cellular signal transduction Development and progression Genetic aspects Glioma - blood supply Glioma - genetics Glioma - metabolism Glioma - pathology Gliomas Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Hematopoietic stem cells Humans Inhibitor of Differentiation Protein 2 - genetics Inhibitor of Differentiation Protein 2 - metabolism Mice Mice, Transgenic Myeloid Cells - metabolism Myeloid Cells - pathology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Signal Transduction Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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