Prenatal Exposure to a Maternal High-Fat Diet Affects Histone Modification of Cardiometabolic Genes in Newborn Rats

Infants born to women with diabetes or obesity are exposed to excess circulating fuels during fetal heart development and are at higher risk of cardiac diseases. We have previously shown that late-gestation diabetes, especially in conjunction with a maternal high-fat (HF) diet, impairs cardiac funct...

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Veröffentlicht in:	Nutrients 2017-04, Vol.9 (4), p.407
Hauptverfasser:	Upadhyaya, Bijaya, Larsen, Tricia, Barwari, Shivon, Louwagie, Eli J, Baack, Michelle L, Dey, Moul
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Animals, Newborn Biosynthesis Blood Pressure blood serum Body Weight Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Cholesterol Cholesterol - blood Chromatin Coronary artery disease Diabetes Diabetes mellitus Diabetes Mellitus, Experimental Diet, High-Fat - adverse effects disease susceptibility Epigenesis, Genetic Epigenetics Exposure Female Fetal Development Fetuses fuels Gene Expression Regulation, Developmental Genes Genetic Association Studies Genetic Predisposition to Disease Genomes Gestation Health risks heart Heart diseases High fat diet Histone Code Histone H3 histones Immunoprecipitation Infants Lysine maternal exposure Maternal Nutritional Physiological Phenomena Metabolic Syndrome - etiology Metabolic Syndrome - genetics neonates obesity Offspring Pregnancy Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects - genetics progeny Promoter Regions, Genetic Promoters pups Quantitative Trait Loci Rats Rats, Sprague-Dawley Rodents Sequence Analysis, DNA women
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