Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches
Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with a range of acute and chronic diseases in humans. However, the specific effects they exert on the stem cells remain unclear. Here, we report the effects of PM collected from the ci...
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| Veröffentlicht in: | International journal of environmental research and public health 2017-04, Vol.14 (4), p.440 |
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| creator | Abu-Elmagd, Muhammad Alghamdi, Mansour A Shamy, Magdy Khoder, Mamdouh I Costa, Max Assidi, Mourad Kadam, Roaa Alsehli, Haneen Gari, Mamdooh Pushparaj, Peter Natesan Kalamegam, Gauthaman Al-Qahtani, Mohammed H |
| description | Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with a range of acute and chronic diseases in humans. However, the specific effects they exert on the stem cells remain unclear. Here, we report the effects of PM collected from the city of Jeddah on proliferation, cell death, related gene expression and systems of biological analysis in bone marrow mesenchymal stem cells (BM-MSCs), with the aim of understanding the underlying mechanisms. PM
and PM
were tested in vitro at various concentrations (15 to 300 µg/mL) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM
increased proliferation of BM-MSCs, while higher concentrations served to decrease it. PM
decreased BM-MSCs proliferation in a concentration-dependent manner. The X-ray fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses demonstrated that heavy metals were associated with signaling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential expression of the apoptosis genes (BCL2, BAX); inflammation associated genes (TNF-α and IL-6) and the cell cycle regulation gene (p53). We conclude that PM causes inflammation and cell death, and thereby predisposes to chronic debilitating diseases. |
| doi_str_mv | 10.3390/ijerph14040440 |
| format | Article |
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and PM
were tested in vitro at various concentrations (15 to 300 µg/mL) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM
increased proliferation of BM-MSCs, while higher concentrations served to decrease it. PM
decreased BM-MSCs proliferation in a concentration-dependent manner. The X-ray fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses demonstrated that heavy metals were associated with signaling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential expression of the apoptosis genes (BCL2, BAX); inflammation associated genes (TNF-α and IL-6) and the cell cycle regulation gene (p53). We conclude that PM causes inflammation and cell death, and thereby predisposes to chronic debilitating diseases.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph14040440</identifier><identifier>PMID: 28425934</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Air Pollutants - toxicity ; Air pollution ; Airborne particulates ; Apoptosis ; Apoptosis - drug effects ; Biological analysis ; Bone marrow ; Bone Marrow Cells - drug effects ; Cell cycle ; Cell death ; Cell growth ; Cell Proliferation - drug effects ; Cellular stress response ; Clustering ; Diseases ; Dose-Response Relationship, Drug ; Dust ; Fluorescence ; Gene expression ; Genes ; Heavy metals ; Humans ; Inflammation ; Interleukin 6 ; Male ; Mesenchymal Stromal Cells - drug effects ; Mesenchyme ; Middle Aged ; Morphology ; Mortality ; p53 Protein ; Particle Size ; Particulate emissions ; Particulate matter ; Particulate Matter - toxicity ; Pollutants ; Saudi Arabia ; Signal Transduction - drug effects ; Spectrometry ; Stem cells ; Tumor necrosis factor-α</subject><ispartof>International journal of environmental research and public health, 2017-04, Vol.14 (4), p.440</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-4f6e0f3c2259fdb9f66256ef06051cc0e69c7bd548c6ad4b479fbc4499c38b043</citedby><cites>FETCH-LOGICAL-c418t-4f6e0f3c2259fdb9f66256ef06051cc0e69c7bd548c6ad4b479fbc4499c38b043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409640/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409640/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28425934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abu-Elmagd, Muhammad</creatorcontrib><creatorcontrib>Alghamdi, Mansour A</creatorcontrib><creatorcontrib>Shamy, Magdy</creatorcontrib><creatorcontrib>Khoder, Mamdouh I</creatorcontrib><creatorcontrib>Costa, Max</creatorcontrib><creatorcontrib>Assidi, Mourad</creatorcontrib><creatorcontrib>Kadam, Roaa</creatorcontrib><creatorcontrib>Alsehli, Haneen</creatorcontrib><creatorcontrib>Gari, Mamdooh</creatorcontrib><creatorcontrib>Pushparaj, Peter Natesan</creatorcontrib><creatorcontrib>Kalamegam, Gauthaman</creatorcontrib><creatorcontrib>Al-Qahtani, Mohammed H</creatorcontrib><title>Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with a range of acute and chronic diseases in humans. However, the specific effects they exert on the stem cells remain unclear. Here, we report the effects of PM collected from the city of Jeddah on proliferation, cell death, related gene expression and systems of biological analysis in bone marrow mesenchymal stem cells (BM-MSCs), with the aim of understanding the underlying mechanisms. PM
and PM
were tested in vitro at various concentrations (15 to 300 µg/mL) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM
increased proliferation of BM-MSCs, while higher concentrations served to decrease it. PM
decreased BM-MSCs proliferation in a concentration-dependent manner. The X-ray fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses demonstrated that heavy metals were associated with signaling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential expression of the apoptosis genes (BCL2, BAX); inflammation associated genes (TNF-α and IL-6) and the cell cycle regulation gene (p53). We conclude that PM causes inflammation and cell death, and thereby predisposes to chronic debilitating diseases.</description><subject>Air Pollutants - toxicity</subject><subject>Air pollution</subject><subject>Airborne particulates</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological analysis</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell growth</subject><subject>Cell Proliferation - drug effects</subject><subject>Cellular stress response</subject><subject>Clustering</subject><subject>Diseases</subject><subject>Dose-Response Relationship, Drug</subject><subject>Dust</subject><subject>Fluorescence</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Male</subject><subject>Mesenchymal Stromal Cells - drug effects</subject><subject>Mesenchyme</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Mortality</subject><subject>p53 Protein</subject><subject>Particle Size</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - toxicity</subject><subject>Pollutants</subject><subject>Saudi Arabia</subject><subject>Signal Transduction - drug effects</subject><subject>Spectrometry</subject><subject>Stem cells</subject><subject>Tumor necrosis factor-α</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkcFu1DAQhiMEoqVw5YgscSkSKfbGcW0OlXZXC1RqBNLC2XKcceNVEgfbabVP01etQ0vVVj7YY3_zyb8my94TfFIUAn-xO_BjSyhOi-IX2SFhDOeUYfLy0fkgexPCDuOCUyZeZwcLThelKOhhdrO5Ut2konUDcgbFFtDGGNAxzOXS-tr5AdAv5aPVU6cioErFCB6lhpUb5tJ7d51XEGDQ7b5XHdpG6NEaui6g41WVV9t1-PT130Uy-M-och3MMo_U0KDtPiQ-oJV1nbu0OgmW4-id0i2Et9kro7oA7-73o-zPt83v9Y_84uf38_XyIteU8JhTwwCbQi9SLNPUwjC2KBkYzHBJtMbAhD6tm5JyzVRDa3oqTK0pFUIXvMa0OMrO7rzjVPfQaBiiV50cve2V30unrHz6MthWXrorWVIsGMVJcHwv8O7vBCHK3gadIqsB3BQk4YJgzoUoE_rxGbpzkx9SvJkSvMCk5Ik6uaO0dyF4MA-fIVjOs5dPZ58aPjyO8ID_H3ZxC7pjrWI</recordid><startdate>20170420</startdate><enddate>20170420</enddate><creator>Abu-Elmagd, Muhammad</creator><creator>Alghamdi, Mansour A</creator><creator>Shamy, Magdy</creator><creator>Khoder, Mamdouh I</creator><creator>Costa, Max</creator><creator>Assidi, Mourad</creator><creator>Kadam, Roaa</creator><creator>Alsehli, Haneen</creator><creator>Gari, Mamdooh</creator><creator>Pushparaj, Peter Natesan</creator><creator>Kalamegam, Gauthaman</creator><creator>Al-Qahtani, Mohammed H</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170420</creationdate><title>Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches</title><author>Abu-Elmagd, Muhammad ; Alghamdi, Mansour A ; Shamy, Magdy ; Khoder, Mamdouh I ; Costa, Max ; Assidi, Mourad ; Kadam, Roaa ; Alsehli, Haneen ; Gari, Mamdooh ; Pushparaj, Peter Natesan ; Kalamegam, Gauthaman ; Al-Qahtani, Mohammed H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-4f6e0f3c2259fdb9f66256ef06051cc0e69c7bd548c6ad4b479fbc4499c38b043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Air Pollutants - toxicity</topic><topic>Air pollution</topic><topic>Airborne particulates</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological analysis</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cell growth</topic><topic>Cell Proliferation - drug effects</topic><topic>Cellular stress response</topic><topic>Clustering</topic><topic>Diseases</topic><topic>Dose-Response Relationship, Drug</topic><topic>Dust</topic><topic>Fluorescence</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Male</topic><topic>Mesenchymal Stromal Cells - drug effects</topic><topic>Mesenchyme</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Mortality</topic><topic>p53 Protein</topic><topic>Particle Size</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - toxicity</topic><topic>Pollutants</topic><topic>Saudi Arabia</topic><topic>Signal Transduction - drug effects</topic><topic>Spectrometry</topic><topic>Stem cells</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abu-Elmagd, Muhammad</creatorcontrib><creatorcontrib>Alghamdi, Mansour A</creatorcontrib><creatorcontrib>Shamy, Magdy</creatorcontrib><creatorcontrib>Khoder, Mamdouh I</creatorcontrib><creatorcontrib>Costa, Max</creatorcontrib><creatorcontrib>Assidi, Mourad</creatorcontrib><creatorcontrib>Kadam, Roaa</creatorcontrib><creatorcontrib>Alsehli, Haneen</creatorcontrib><creatorcontrib>Gari, Mamdooh</creatorcontrib><creatorcontrib>Pushparaj, Peter Natesan</creatorcontrib><creatorcontrib>Kalamegam, Gauthaman</creatorcontrib><creatorcontrib>Al-Qahtani, Mohammed H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abu-Elmagd, Muhammad</au><au>Alghamdi, Mansour A</au><au>Shamy, Magdy</au><au>Khoder, Mamdouh I</au><au>Costa, Max</au><au>Assidi, Mourad</au><au>Kadam, Roaa</au><au>Alsehli, Haneen</au><au>Gari, Mamdooh</au><au>Pushparaj, Peter Natesan</au><au>Kalamegam, Gauthaman</au><au>Al-Qahtani, Mohammed H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2017-04-20</date><risdate>2017</risdate><volume>14</volume><issue>4</issue><spage>440</spage><pages>440-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with a range of acute and chronic diseases in humans. However, the specific effects they exert on the stem cells remain unclear. Here, we report the effects of PM collected from the city of Jeddah on proliferation, cell death, related gene expression and systems of biological analysis in bone marrow mesenchymal stem cells (BM-MSCs), with the aim of understanding the underlying mechanisms. PM
and PM
were tested in vitro at various concentrations (15 to 300 µg/mL) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM
increased proliferation of BM-MSCs, while higher concentrations served to decrease it. PM
decreased BM-MSCs proliferation in a concentration-dependent manner. The X-ray fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses demonstrated that heavy metals were associated with signaling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential expression of the apoptosis genes (BCL2, BAX); inflammation associated genes (TNF-α and IL-6) and the cell cycle regulation gene (p53). We conclude that PM causes inflammation and cell death, and thereby predisposes to chronic debilitating diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28425934</pmid><doi>10.3390/ijerph14040440</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Air Pollutants - toxicity Air pollution Airborne particulates Apoptosis Apoptosis - drug effects Biological analysis Bone marrow Bone Marrow Cells - drug effects Cell cycle Cell death Cell growth Cell Proliferation - drug effects Cellular stress response Clustering Diseases Dose-Response Relationship, Drug Dust Fluorescence Gene expression Genes Heavy metals Humans Inflammation Interleukin 6 Male Mesenchymal Stromal Cells - drug effects Mesenchyme Middle Aged Morphology Mortality p53 Protein Particle Size Particulate emissions Particulate matter Particulate Matter - toxicity Pollutants Saudi Arabia Signal Transduction - drug effects Spectrometry Stem cells Tumor necrosis factor-α |
| title | Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches |
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