Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

P-glycoprotein (P-gp) is a multidrug transporter that uses energy from ATP hydrolysis to export many structurally dissimilar hydrophobic and amphipathic compounds, including anticancer drugs from cells. Several structural studies on purified P-gp have been reported, but only limited and sometimes co...

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Veröffentlicht in:	The Journal of biological chemistry 2017-04, Vol.292 (17), p.7066-7076
Hauptverfasser:	Shukla, Suneet, Abel, Biebele, Chufan, Eduardo E., Ambudkar, Suresh V.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Acridines - chemistry Adenosine Triphosphate - chemistry Animals ATP Binding Cassette Transporter, Subfamily B - chemistry ATP hydrolysis Baculoviridae - metabolism Binding Sites detergent micelles Detergents - chemistry Dibenzocycloheptenes - chemistry docking Drug Delivery Systems Drug Evaluation, Preclinical drug resistance Glucosides - chemistry Humans Hydrolysis Inhibitory Concentration 50 Insecta Ligands Membrane Biology Mice Micelles molecular modeling multidrug transporter nanodiscs P-glycoprotein Peptides, Cyclic - chemistry Protein Binding proteoliposomes Quinolines - chemistry Tetrahydroisoquinolines - chemistry Verapamil - chemistry
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