High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

Excessive fat intake contributes to the progression of metabolic diseases cellular injury and inflammation, a process termed lipotoxicity. Here, we investigated the role of lysosomal dysfunction and impaired autophagic flux in the pathogenesis of lipotoxicity in the kidney. In mice, a high-fat diet...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2017-05, Vol.28 (5), p.1534-1551
Hauptverfasser:	Yamamoto, Takeshi, Takabatake, Yoshitsugu, Takahashi, Atsushi, Kimura, Tomonori, Namba, Tomoko, Matsuda, Jun, Minami, Satoshi, Kaimori, Jun-Ya, Matsui, Isao, Matsusaka, Taiji, Niimura, Fumio, Yanagita, Motoko, Isaka, Yoshitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - drug effects Autophagy - physiology Basic Research Diet, High-Fat - adverse effects Kidney - drug effects Kidney - metabolism Kidney Diseases - etiology Lipid Metabolism - drug effects Lysosomes - drug effects Lysosomes - physiology Male Mice Palmitic Acid - pharmacology
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