Phenotypic switch: The enigmatic white-gray-opaque transition system of Candida albicans
represents the most common commensal and opportunistic fungal pathogen colonizing humans. As a member of the normal microflora, it is present on the skin and the mucous membranes of the upper respiratory tract, gastrointestinal tract and female genital tracts. It is therefore not transmitted. It lie...
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| Veröffentlicht in: | Journal of oral and maxillofacial pathology : JOMFP 2017-01, Vol.21 (1), p.82-86 |
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| creator | Bommanavar, Sushma Basavaraj Gugwad, Sachin Malik, Neelima |
| description | represents the most common commensal and opportunistic fungal pathogen colonizing humans. As a member of the normal microflora, it is present on the skin and the mucous membranes of the upper respiratory tract, gastrointestinal tract and female genital tracts. It is therefore not transmitted. It lies in wait for a change in some aspect of the host physiology that normally suppress growth and invasiveness through an enigmatic phenomenon called Phenotypic Switch System or White-Opaque Transition. This system involves reversible and heritable switching between alternative cellular phenotypes. White-opaque switching in
was first discovered in 1987. This was initially identified in strain WO-1. Switching has been demonstrated to occur at sites of infection and to occur between recurrent episodes of infection in select cases esp. AIDS and diabetes. |
| doi_str_mv | 10.4103/0973-029X.203781 |
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was first discovered in 1987. This was initially identified in strain WO-1. Switching has been demonstrated to occur at sites of infection and to occur between recurrent episodes of infection in select cases esp. AIDS and diabetes.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Antigens</subject><subject>Candida albicans</subject><subject>Dendritic cells</subject><subject>Diabetes mellitus</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Immune system</subject><subject>Infections</subject><subject>Invasiveness</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Morphology</subject><subject>Neutrophils</subject><subject>Opportunist infection</subject><subject>Pathogenesis</subject><subject>Phenotypes</subject><subject>Recurrent infection</subject><subject>Respiratory tract</subject><subject>Review</subject><subject>Skin</subject><subject>Virulence (Microbiology)</subject><issn>0973-029X</issn><issn>1998-393X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk1rGzEQFaWlcdPeeyoLvfSyzujLK_VQCKZfEGgOCfgmtPrwKuxK7mrd4H9fLU7dJhQJBDPvvZmnGYTeYlgyDPQCZENrIHKzJEAbgZ-hBZZS1FTSzXO0OKXP0Kuc7wC4YJy8RGdEsEauJFmgzXXnYpoOu2CqfB8m032sbjpXuRi2g55K9L4Lk6u3oz7Uaad_7l01jTrmMIUUq3zIkxuq5Ku1jjZYXem-DabkX6MXXvfZvXl4z9Htl88362_11Y-v39eXV7VhsMK1aCVvDWtY2zJrLZNAMOaMlysZYPDOU84bqj0z3miKuSWeQAPcNoS0mp6jT0fd3b4dnDUulvZ6tRvDoMeDSjqox5kYOrVNvxQv9QXhReDDg8CYirs8qSFk4_peR5f2WWEhVwwkJbRA3z-B3qX9GIs9VbomuHRK8V_UVvdOhehTqWtmUXVZ_IEgWMxay_-gyrFuCCZF50OJPyLAkWDGlPPo_MkjBjVvg5rHreZxq-M2FMq7f__mRPgzfvobxpSurA</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Bommanavar, Sushma Basavaraj</creator><creator>Gugwad, Sachin</creator><creator>Malik, Neelima</creator><general>Medknow Publications and Media Pvt. 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| ispartof | Journal of oral and maxillofacial pathology : JOMFP, 2017-01, Vol.21 (1), p.82-86 |
| issn | 0973-029X 1998-393X |
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| source | PubMed (Medline); Medknow Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central Open Access |
| subjects | Acquired immune deficiency syndrome AIDS Antigens Candida albicans Dendritic cells Diabetes mellitus Gastrointestinal tract Gene expression Genetic aspects Genotype & phenotype Health aspects Immune system Infections Invasiveness Metabolism Microbiota Morphology Neutrophils Opportunist infection Pathogenesis Phenotypes Recurrent infection Respiratory tract Review Skin Virulence (Microbiology) |
| title | Phenotypic switch: The enigmatic white-gray-opaque transition system of Candida albicans |
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