MicroRNA‐9 plays a role in interleukin‐10‐mediated expression of E‐cadherin in acute myelogenous leukemia cells

We previously showed that the CD82/signal transducer and activator of transcription/interleukin‐10 (IL‐10) axis is activated in CD34+/CD38− AML cells that favor the bone marrow microenvironment. The present study explored the novel biological function of IL‐10 in regulation of expression of adhesion...

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Veröffentlicht in:	Cancer science 2017-04, Vol.108 (4), p.685-695
Hauptverfasser:	Nishioka, Chie, Ikezoe, Takayuki, Pan, Bin, Xu, Kailin, Yokoyama, Akihito
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Acute Disease AML Animals Antimetabolites, Antineoplastic - pharmacology Blotting, Western Cadherins - genetics Cadherins - metabolism Cell Adhesion - drug effects Cell Adhesion - genetics Cell Line, Tumor Cells, Cultured CpG Islands - genetics Cytarabine - pharmacology DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation - drug effects DNMT3A E‐cadherin Gene Expression Regulation, Leukemic - drug effects Humans IL‐10 Interleukin-10 - pharmacology Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - pathology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mice, Inbred NOD Mice, Knockout MicroRNAs - genetics miR‐9 Original Reverse Transcriptase Polymerase Chain Reaction RNA Interference Survival Analysis Xenograft Model Antitumor Assays
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