Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

Background and Purpose Insulin‐like peptide 5 (INSL5) is a two‐chain, three‐disulfide‐bonded peptide of the insulin/relaxin superfamily, uniquely expressed in enteroendocrine L‐cells of the colon. It is the cognate ligand of relaxin family peptide RXFP4 receptor that is mainly expressed in the color...

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Veröffentlicht in:	British journal of pharmacology 2017-05, Vol.174 (10), p.1077-1089
Hauptverfasser:	Ang, Sheng Y, Hutchinson, Dana S, Patil, Nitin, Evans, Bronwyn A, Bathgate, Ross A D, Halls, Michelle L, Hossain, Mohammed A, Summers, Roger J, Kocan, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation AKT protein Animals b-Adrenergic-receptor kinase Bromodeoxyuridine Calcium (intracellular) Cell proliferation Cell Proliferation - drug effects Cells, Cultured CHO Cells Colon Colorectal cancer Cricetulus Cyclic AMP Cyclic AMP - antagonists & inhibitors Cyclic AMP - metabolism Dose-Response Relationship, Drug Enteric nervous system Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Forskolin G protein-coupled receptors Gene expression Humans Insulin Insulin - pharmacology Insulin secretion Insulinoma K-Ras protein Kinases Mice Mutants Neuroendocrine tumors p38 Mitogen-Activated Protein Kinases - metabolism Peptides Pertussis Pertussis toxin Phosphorylation Proteins Proteins - pharmacology Proto-Oncogene Proteins c-akt - metabolism Receptor mechanisms Receptors, G-Protein-Coupled - metabolism Receptors, Peptide - metabolism Relaxin Research Paper Ribosomal Protein S6 - metabolism Secretion Signal transduction Signal Transduction - drug effects Structure-Activity Relationship Themed Section: Research Paper Transfection
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