Curcuminoid EF24 enhances the anti‐tumour activity of Akt inhibitor MK‐2206 through ROS‐mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer

Background and Purpose Gastric cancer is one of the leading causes of morbidity and mortality worldwide. Akt is an anti‐apoptotic kinase that plays a dynamic role in cell survival and is implicated in the pathogenesis of gastric cancer. MK‐2206, the first allosteric inhibitor of Akt, is in clinical...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2017-05, Vol.174 (10), p.1131-1146
Hauptverfasser:	Chen, Xi, Dai, Xuanxuan, Zou, Peng, Chen, Weiqian, Rajamanickam, Vinothkumar, Feng, Chen, Zhuge, Weishan, Qiu, Chenyu, Ye, Qingqing, Zhang, Xiaohua, Liang, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Allosteric properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Benzylidene Compounds - chemistry Benzylidene Compounds - pharmacology Cancer therapies Cell cycle Cell death Cell Proliferation - drug effects Cell survival Cell Survival - drug effects Cells, Cultured Clinical trials Combined treatment Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Electron microscopy Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Gastric cancer Heterocyclic Compounds, 3-Ring - chemistry Heterocyclic Compounds, 3-Ring - pharmacology Humans Immunodeficiency Mitochondria Mitochondria - drug effects Mitochondria - metabolism Morbidity Oncogene Protein v-akt - antagonists & inhibitors Oncogene Protein v-akt - metabolism Phosphorylation - drug effects Piperidones - chemistry Piperidones - pharmacology Reactive Oxygen Species - metabolism Research Paper Research Papers Rodents Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stress Structure-Activity Relationship Tumors Western blotting Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!