Dopamine D2/D3 imbalance during migraine attack and allodynia in vivo

OBJECTIVE:To evaluate in vivo the dynamics of endogenous dopamine (DA) neurotransmission during migraine ictus with allodynia. METHODS:We examined 8 episodic migraineurs and 8 healthy controls (HC) using PET with [C]raclopride. The uptake measure of [C]raclopride, nondisplaceable binding potential (...

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Veröffentlicht in:	Neurology 2017-04, Vol.88 (17), p.1634-1641
Hauptverfasser:	DaSilva, Alexandre F, Nascimento, Thiago D, Jassar, Hassan, Heffernan, Joseph, Toback, Rebecca L, Lucas, Sarah, DosSantos, Marcos F, Bellile, Emily L, Boonstra, Philip S, Taylor, Jeremy M.G, Casey, Kenneth L, Koeppe, Robert A, Smith, Yolanda R, Zubieta, Jon-Kar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brain - metabolism Brain Mapping Dopamine - metabolism Female Hot Temperature Humans Hyperalgesia - diagnostic imaging Hyperalgesia - metabolism Male Migraine with Aura - diagnostic imaging Migraine with Aura - metabolism Migraine without Aura - diagnostic imaging Migraine without Aura - metabolism Physical Stimulation Positron-Emission Tomography Raclopride Radiopharmaceuticals Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - metabolism Rest Synaptic Transmission - physiology Young Adult
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