The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue

Objective Oxygen transport to parenchymal cells occurs mainly at the microvascular level and depends on convective RBC flux, which is proportional in an individual capillary to the product of capillary hematocrit and RBC velocity. This study investigates the relative influence of these two factors o...

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Veröffentlicht in:	Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2017-04, Vol.24 (3), p.n/a
Hauptverfasser:	Lücker, Adrien, Secomb, Timothy W., Weber, Bruno, Jenny, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport blood flow Blood Flow Velocity Capillaries - metabolism Erythrocytes - physiology Hematocrit Humans Influence mathematical modeling Models, Biological Oxygen Oxygen - metabolism Oxygen Consumption tissue oxygenation Velocity
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creator	Lücker, Adrien Secomb, Timothy W. Weber, Bruno Jenny, Patrick
description	Objective Oxygen transport to parenchymal cells occurs mainly at the microvascular level and depends on convective RBC flux, which is proportional in an individual capillary to the product of capillary hematocrit and RBC velocity. This study investigates the relative influence of these two factors on tissue PO2. Methods A simple analytical model is used to quantify the respective influences of hematocrit, RBC velocity, and RBC flow on tissue oxygenation around capillaries. Predicted tissue PO2 levels are compared with a detailed computational model. Results Hematocrit is shown to have a larger influence on tissue PO2 than RBC velocity. The effect of RBC velocity increases with distance from the arterioles. Good agreement between analytical and numerical results is obtained, and the discrepancies are explained. Significant dependence of MTCs on RBC velocity at low hematocrit is demonstrated. Conclusions For a given RBC flux in a capillary, the PO2 in the surrounding tissue increases with increasing hematocrit, as a consequence of decreasing IVR to diffusive oxygen transport from RBCs to tissue. These results contribute to understanding the effects of blood flow changes on oxygen transport, such as those that occur in functional hyperemia in the brain.
doi_str_mv	10.1111/micc.12337
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This study investigates the relative influence of these two factors on tissue PO2. Methods A simple analytical model is used to quantify the respective influences of hematocrit, RBC velocity, and RBC flow on tissue oxygenation around capillaries. Predicted tissue PO2 levels are compared with a detailed computational model. Results Hematocrit is shown to have a larger influence on tissue PO2 than RBC velocity. The effect of RBC velocity increases with distance from the arterioles. Good agreement between analytical and numerical results is obtained, and the discrepancies are explained. Significant dependence of MTCs on RBC velocity at low hematocrit is demonstrated. Conclusions For a given RBC flux in a capillary, the PO2 in the surrounding tissue increases with increasing hematocrit, as a consequence of decreasing IVR to diffusive oxygen transport from RBCs to tissue. These results contribute to understanding the effects of blood flow changes on oxygen transport, such as those that occur in functional hyperemia in the brain.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/micc.12337</identifier><identifier>PMID: 27893186</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biological Transport ; blood flow ; Blood Flow Velocity ; Capillaries - metabolism ; Erythrocytes - physiology ; Hematocrit ; Humans ; Influence ; mathematical modeling ; Models, Biological ; Oxygen ; Oxygen - metabolism ; Oxygen Consumption ; tissue oxygenation ; Velocity</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2017-04, Vol.24 (3), p.n/a</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4487-abb0c5df7373fb0017a66ee291a471a51c29551329ac104f103675207b267cb93</citedby><cites>FETCH-LOGICAL-c4487-abb0c5df7373fb0017a66ee291a471a51c29551329ac104f103675207b267cb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmicc.12337$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmicc.12337$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27925,27926,45575,45576</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27893186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lücker, Adrien</creatorcontrib><creatorcontrib>Secomb, Timothy W.</creatorcontrib><creatorcontrib>Weber, Bruno</creatorcontrib><creatorcontrib>Jenny, Patrick</creatorcontrib><title>The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objective Oxygen transport to parenchymal cells occurs mainly at the microvascular level and depends on convective RBC flux, which is proportional in an individual capillary to the product of capillary hematocrit and RBC velocity. This study investigates the relative influence of these two factors on tissue PO2. Methods A simple analytical model is used to quantify the respective influences of hematocrit, RBC velocity, and RBC flow on tissue oxygenation around capillaries. Predicted tissue PO2 levels are compared with a detailed computational model. Results Hematocrit is shown to have a larger influence on tissue PO2 than RBC velocity. The effect of RBC velocity increases with distance from the arterioles. Good agreement between analytical and numerical results is obtained, and the discrepancies are explained. Significant dependence of MTCs on RBC velocity at low hematocrit is demonstrated. Conclusions For a given RBC flux in a capillary, the PO2 in the surrounding tissue increases with increasing hematocrit, as a consequence of decreasing IVR to diffusive oxygen transport from RBCs to tissue. These results contribute to understanding the effects of blood flow changes on oxygen transport, such as those that occur in functional hyperemia in the brain.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>blood flow</subject><subject>Blood Flow Velocity</subject><subject>Capillaries - metabolism</subject><subject>Erythrocytes - physiology</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Influence</subject><subject>mathematical modeling</subject><subject>Models, Biological</subject><subject>Oxygen</subject><subject>Oxygen - metabolism</subject><subject>Oxygen Consumption</subject><subject>tissue oxygenation</subject><subject>Velocity</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqFTEUhoMotlY3PoAE3AlTcyYzk2QjyEVroeKmrkMmc6Y3JZNck8zV-_amvbXoxmxO4Hx854efkNfAzqG-94uz9hxazsUTcgp9pxopQD2tfyZ4owYpT8iLnG8ZY1K26jk5aYVUHORwSuL1FmlCb4rbI3Vh9isGizTOdIuLKdEmV6gJU4UmOvoYJ2rRe7pHH60rBxoDjb8ONxhoSSbkXUyFziku1Jqd894kh5mWSIvLecWX5NlsfMZXD_OMfP_86Xrzpbn6dnG5-XjV2K6TojHjyGw_zYILPo-MgTDDgNgqMJ0A04NtVd8Db5WxwLoZGB9E3zIxtoOwo-Jn5MPRu1vHBSeLoabzepfcYtJBR-P0v5vgtvom7nXfsU71rArePghS_LFiLvo2rinUzBqkAi4GJoZKvTtSNsWcE86PF4Dpu3L0XTn6vpwKv_k70yP6p40KwBH46Twe_qPSXy83m6P0NzGIm9o</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Lücker, Adrien</creator><creator>Secomb, Timothy W.</creator><creator>Weber, Bruno</creator><creator>Jenny, Patrick</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201704</creationdate><title>The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue</title><author>Lücker, Adrien ; Secomb, Timothy W. ; Weber, Bruno ; Jenny, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4487-abb0c5df7373fb0017a66ee291a471a51c29551329ac104f103675207b267cb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>blood flow</topic><topic>Blood Flow Velocity</topic><topic>Capillaries - metabolism</topic><topic>Erythrocytes - physiology</topic><topic>Hematocrit</topic><topic>Humans</topic><topic>Influence</topic><topic>mathematical modeling</topic><topic>Models, Biological</topic><topic>Oxygen</topic><topic>Oxygen - metabolism</topic><topic>Oxygen Consumption</topic><topic>tissue oxygenation</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lücker, Adrien</creatorcontrib><creatorcontrib>Secomb, Timothy W.</creatorcontrib><creatorcontrib>Weber, Bruno</creatorcontrib><creatorcontrib>Jenny, Patrick</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lücker, Adrien</au><au>Secomb, Timothy W.</au><au>Weber, Bruno</au><au>Jenny, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2017-04</date><risdate>2017</risdate><volume>24</volume><issue>3</issue><epage>n/a</epage><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Objective Oxygen transport to parenchymal cells occurs mainly at the microvascular level and depends on convective RBC flux, which is proportional in an individual capillary to the product of capillary hematocrit and RBC velocity. This study investigates the relative influence of these two factors on tissue PO2. Methods A simple analytical model is used to quantify the respective influences of hematocrit, RBC velocity, and RBC flow on tissue oxygenation around capillaries. Predicted tissue PO2 levels are compared with a detailed computational model. Results Hematocrit is shown to have a larger influence on tissue PO2 than RBC velocity. The effect of RBC velocity increases with distance from the arterioles. Good agreement between analytical and numerical results is obtained, and the discrepancies are explained. Significant dependence of MTCs on RBC velocity at low hematocrit is demonstrated. Conclusions For a given RBC flux in a capillary, the PO2 in the surrounding tissue increases with increasing hematocrit, as a consequence of decreasing IVR to diffusive oxygen transport from RBCs to tissue. These results contribute to understanding the effects of blood flow changes on oxygen transport, such as those that occur in functional hyperemia in the brain.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27893186</pmid><doi>10.1111/micc.12337</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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subjects	Animals Biological Transport blood flow Blood Flow Velocity Capillaries - metabolism Erythrocytes - physiology Hematocrit Humans Influence mathematical modeling Models, Biological Oxygen Oxygen - metabolism Oxygen Consumption tissue oxygenation Velocity
title	The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue
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