Altered expression of histone deacetylases, inflammatory cytokines and contractile-associated factors in uterine myometrium of Long Evans rats gestationally exposed to benzo[a]pyrene

Etiology of preterm birth (PTB) is multifactorial; therefore, decreasing the incidence of PTB is a major challenge in the field of obstetrics. Epidemiological studies have reported an association between toxicants and PTB. However, there are no studies on the role of benzo[a]pyrene (BaP), an environ...

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Veröffentlicht in:	Journal of applied toxicology 2016-06, Vol.36 (6), p.827-835
Hauptverfasser:	Laknaur, Archana, Foster, Terri-Lee, Bobb, Lesley E., Ramesh, Aramandla, Ladson, Gwinnett M., Hood, Darryl B., Al-Hendy, Ayman, Thota, Chandrasekhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Benzo(a)pyrene Benzo(a)pyrene - administration & dosage Benzo(a)pyrene - metabolism Benzo(a)pyrene - toxicity Biotransformation Carcinogens, Environmental - administration & dosage Carcinogens, Environmental - metabolism Carcinogens, Environmental - toxicity connexin 43 connexin 43, Cox2 Correlation Cox2 Cytokines Cytokines - agonists Cytokines - genetics Cytokines - metabolism Dose-Response Relationship, Drug Environmental toxicant Exposure Female Gene Expression Regulation, Developmental - drug effects Histone deacetylases Histone Deacetylases - chemistry Histone Deacetylases - genetics Histone Deacetylases - metabolism Histones Histopathology Incidence inflammatory cytokines Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Metabolites Myometrium - drug effects Myometrium - immunology Myometrium - metabolism Myometrium - pathology NFқB Polycyclic aromatic hydrocarbons Pregnancy Premature birth Premature Birth - etiology Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - pathology Prenatal Exposure Delayed Effects - physiopathology Preterm birth Random Allocation Rats Rats, Long-Evans Tissue Distribution Toxicokinetics Toxicology Transcription Factor RelA - agonists Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Uterine myometrium Uterus
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