The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations

The JmjC histone lysine demethylases (KDMs) are epigenetic regulators involved in the removal of methyl groups from post-translationally modified lysyl residues within histone tails, modulating gene transcription. These enzymes require molecular oxygen for catalytic activity and, as 2-oxoglutarate (...

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Veröffentlicht in:	ACS chemical biology 2017-04, Vol.12 (4), p.1011-1019
Hauptverfasser:	Hancock, Rebecca L, Masson, Norma, Dunne, Kate, Flashman, Emily, Kawamura, Akane
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromatin - metabolism Fluorescent Antibody Technique Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Kinetics Oxygen - metabolism Pseudogenes
Online-Zugang:	Volltext
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