Protection of Nrf2 against arsenite‐induced oxidative damage is regulated by the cyclic guanosine monophosphate‐protein kinase G signaling pathway

ABSTRACT Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite‐tr...

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Veröffentlicht in:	Environmental toxicology 2017-08, Vol.32 (8), p.2004-2020
Hauptverfasser:	Chen, Chengzhi, Jiang, Xuejun, Gu, Shiyan, Lai, Yanhao, Liu, Yuan, Zhang, Zunzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Activation analysis Antioxidants Antioxidants - metabolism Arsenite Arsenites - toxicity Breakage Cell Line cGMP‐PKG signaling pathway Cyclic GMP Cyclic GMP-Dependent Protein Kinases - metabolism Deoxyribonucleic acid DNA DNA damage Guanosine Humans Hydroquinones - pharmacology Impact damage Isothiocyanates - pharmacology Kinases Lipid peroxidation Mammalian cells Mammals NF-E2-Related Factor 2 - agonists NF-E2-Related Factor 2 - metabolism Nrf2 Overexpression oxidative damage Oxidative Stress - drug effects Peroxidation Protein kinase Protein kinase G Proteins Side effects Signal Transduction Sulforaphane Time dependence Toxicity
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