Apamin suppresses biliary fibrosis and activation of hepatic stellate cells

Cholestatic liver disease is characterized by the progressive destruction of biliary epithelial cells (BECs) followed by fibrosis, cirrhosis and liver failure. Activated hepatic stellate cells (HSCs) and portal fibroblasts are the major cellular effectors of enhanced collagen deposition in biliary f...

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Veröffentlicht in:	International journal of molecular medicine 2017-05, Vol.39 (5), p.1188-1194
Hauptverfasser:	Kim, Jung-Yeon, An, Hyun-Jin, Kim, Woon-Hae, Park, Yoon-Yub, Park, Kyung Duck, Park, Kwan-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apamin - pharmacology Bile Biopsy Care and treatment Cell Proliferation - drug effects Collagen Cytokines - metabolism Development and progression Diet Disease Models, Animal Extracellular Matrix - metabolism Fibroblasts Fibrosis Growth factors Health aspects Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Immunoglobulins Inflammation Mediators - metabolism Liver cirrhosis Liver Cirrhosis, Biliary - etiology Liver Cirrhosis, Biliary - metabolism Liver Cirrhosis, Biliary - pathology Liver diseases Male Mice Neurotoxic agents Proteins Rodents Signal Transduction - drug effects Smad Proteins - metabolism Statistical analysis Studies Tumor necrosis factor-TNF Venom
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