The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1

The stromal microenvironment controls response to injury and inflammation, and is also an important determinant of cancer cell behavior. However, our understanding of its modulation by miRNA (miR) and their respective targets is still sparse. Here, we identified the miR-25-93-106b cluster and two ne...

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Veröffentlicht in:	Oncotarget 2017-03, Vol.8 (13), p.21609-21625
Hauptverfasser:	Cioffi, Michele, Trabulo, Sara M, Vallespinos, Mireia, Raj, Deepak, Kheir, Tony Bou, Lin, Meng-Lay, Begum, Julfa, Baker, Ann-Marie, Amgheib, Ala, Saif, Jaimy, Perez, Manuel, Soriano, Joaquim, Desco, Manuel, Gomez-Gaviro, Maria Victoria, Cusso, Lorena, Megias, Diego, Aicher, Alexandra, Heeschen, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-H1 Antigen - metabolism Chemokine CXCL12 - metabolism Flow Cytometry Gene Expression Regulation, Neoplastic - genetics Gene Knockout Techniques Humans Immunohistochemistry In Situ Hybridization Mice MicroRNAs - genetics Multigene Family - genetics Neoplasm Invasiveness - genetics Polymerase Chain Reaction Research Paper Tumor Escape - genetics
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