Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study
Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effect...
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| description | Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effects on the QOL. We aimed to record these chronic complications, to estimate the QOL, and to identify the corresponding risk factors in patients with SCD receiving care in three hospitals in Cameroon.
In this cross-sectional study, a questionnaire was used to collect data from consecutive consenting patients. Information recorded included data on the yearly frequency of painful crisis, the types of SCD, and the occurrence of chronic complications. A 36-Item Short Form (SF-36) standard questionnaire that examines the level of physical and mental well-being, was administered to all eligible participants. Data were analyzed with STATA® software.
Of 175 participants included, 93 (53.1%) were female and 111 (aged ≥14 years) were eligible for QOL assessment. The median (interquartile range, IQR) age at diagnosis was 4.0 (2.0-8.0) years and the median (IQR) number of yearly painful crisis was 3.0 (1.0-7.0). The most frequent chronic complications reported were: nocturnal enuresis, chronic leg ulcers, osteomyelitis and priapism (30.9%, 24.6%, 19.4%, and 18.3% respectively). The prevalence of stroke and avascular necrosis of the hip were 8.0% and 13.1% respectively. The median (IQR) physical and mental scores were 47.3 (43.9-58.5) and 41.0 (38.8-44.6) respectively. Age and chronic complications such as stroke and avascular necrosis were independently associated with poor QOL.
In this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications. |
| doi_str_mv | 10.1186/s12878-017-0079-7 |
| format | Article |
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In this cross-sectional study, a questionnaire was used to collect data from consecutive consenting patients. Information recorded included data on the yearly frequency of painful crisis, the types of SCD, and the occurrence of chronic complications. A 36-Item Short Form (SF-36) standard questionnaire that examines the level of physical and mental well-being, was administered to all eligible participants. Data were analyzed with STATA® software.
Of 175 participants included, 93 (53.1%) were female and 111 (aged ≥14 years) were eligible for QOL assessment. The median (interquartile range, IQR) age at diagnosis was 4.0 (2.0-8.0) years and the median (IQR) number of yearly painful crisis was 3.0 (1.0-7.0). The most frequent chronic complications reported were: nocturnal enuresis, chronic leg ulcers, osteomyelitis and priapism (30.9%, 24.6%, 19.4%, and 18.3% respectively). The prevalence of stroke and avascular necrosis of the hip were 8.0% and 13.1% respectively. The median (IQR) physical and mental scores were 47.3 (43.9-58.5) and 41.0 (38.8-44.6) respectively. Age and chronic complications such as stroke and avascular necrosis were independently associated with poor QOL.
In this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications.</description><identifier>ISSN: 2052-1839</identifier><identifier>EISSN: 2052-1839</identifier><identifier>EISSN: 1471-2326</identifier><identifier>DOI: 10.1186/s12878-017-0079-7</identifier><identifier>PMID: 28439419</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adults ; Anemia ; Cross-sectional studies ; Gangrene ; Hemoglobin ; Hospitals ; Leg ulcers ; Medical records ; Medical screening ; Mortality ; Quality of life ; Questionnaires ; Sickle cell disease ; Stroke ; Vaccines ; Well being</subject><ispartof>BMC blood disorders, 2017-04, Vol.17 (1), p.7-7, Article 7</ispartof><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3907-3905688a12c8928d5b73f4441b0a30425c2f552667f73cac831eae16a8039acf3</citedby><cites>FETCH-LOGICAL-c3907-3905688a12c8928d5b73f4441b0a30425c2f552667f73cac831eae16a8039acf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399423/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399423/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28439419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andong, Anne M</creatorcontrib><creatorcontrib>Ngouadjeu, Eveline D T</creatorcontrib><creatorcontrib>Bekolo, Cavin E</creatorcontrib><creatorcontrib>Verla, Vincent S</creatorcontrib><creatorcontrib>Nebongo, Daniel</creatorcontrib><creatorcontrib>Mboue-Djieka, Yannick</creatorcontrib><creatorcontrib>Choukem, Simeon-Pierre</creatorcontrib><title>Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study</title><title>BMC blood disorders</title><addtitle>BMC Hematol</addtitle><description>Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effects on the QOL. We aimed to record these chronic complications, to estimate the QOL, and to identify the corresponding risk factors in patients with SCD receiving care in three hospitals in Cameroon.
In this cross-sectional study, a questionnaire was used to collect data from consecutive consenting patients. Information recorded included data on the yearly frequency of painful crisis, the types of SCD, and the occurrence of chronic complications. A 36-Item Short Form (SF-36) standard questionnaire that examines the level of physical and mental well-being, was administered to all eligible participants. Data were analyzed with STATA® software.
Of 175 participants included, 93 (53.1%) were female and 111 (aged ≥14 years) were eligible for QOL assessment. The median (interquartile range, IQR) age at diagnosis was 4.0 (2.0-8.0) years and the median (IQR) number of yearly painful crisis was 3.0 (1.0-7.0). The most frequent chronic complications reported were: nocturnal enuresis, chronic leg ulcers, osteomyelitis and priapism (30.9%, 24.6%, 19.4%, and 18.3% respectively). The prevalence of stroke and avascular necrosis of the hip were 8.0% and 13.1% respectively. The median (IQR) physical and mental scores were 47.3 (43.9-58.5) and 41.0 (38.8-44.6) respectively. Age and chronic complications such as stroke and avascular necrosis were independently associated with poor QOL.
In this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications.</description><subject>Adults</subject><subject>Anemia</subject><subject>Cross-sectional studies</subject><subject>Gangrene</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Leg ulcers</subject><subject>Medical records</subject><subject>Medical screening</subject><subject>Mortality</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Sickle cell disease</subject><subject>Stroke</subject><subject>Vaccines</subject><subject>Well being</subject><issn>2052-1839</issn><issn>2052-1839</issn><issn>1471-2326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUstu1TAQjRAVrdp-ABtkiQ2bFD-S2GaBhK5oQarEBtbWXGfSuDhxaiet7t_wqXXuLVXBsjzWzDmjeZyieMvoBWOq-ZgYV1KVlMmSUqlL-ao44bTmJVNCv37xPy7OU7ql-ShVM1G_KY65qoSumD4p_mz6GEZniQ3D5J2F2YUxERhbcreAd_OOhI541-FqpxzGcU7Zce_GG_Lg5p4kZ397JBa9J61LCAn3_IgWDzALEYkbydxHRNKHNLkZfFpdGxgwhjB-IkBsDCmVCe1aA3iS5qXdnRVHXcbi-ZM9LX5dfv25-VZe_7j6vvlyXVqhqSzzUzdKAeNWaa7aeitFV1UV21IQtOK15V1d86aRnRQWrBIMAVkDigoNthOnxedD3mnZDtja3GYEb6boBog7E8CZfyOj681NuDe10LriIif48JQghrsF02wGl9ahwIhhSYYpnW_elMrQ9_9Bb8MSc8t7lJBSsEZmFDug9nOJ2D0Xw6hZJWAOEjBZAmaVgFk571528cz4u3DxCPV-rwc</recordid><startdate>20170420</startdate><enddate>20170420</enddate><creator>Andong, Anne M</creator><creator>Ngouadjeu, Eveline D T</creator><creator>Bekolo, Cavin E</creator><creator>Verla, Vincent S</creator><creator>Nebongo, Daniel</creator><creator>Mboue-Djieka, Yannick</creator><creator>Choukem, Simeon-Pierre</creator><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170420</creationdate><title>Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study</title><author>Andong, Anne M ; Ngouadjeu, Eveline D T ; Bekolo, Cavin E ; Verla, Vincent S ; Nebongo, Daniel ; Mboue-Djieka, Yannick ; Choukem, Simeon-Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3907-3905688a12c8928d5b73f4441b0a30425c2f552667f73cac831eae16a8039acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adults</topic><topic>Anemia</topic><topic>Cross-sectional studies</topic><topic>Gangrene</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Leg ulcers</topic><topic>Medical records</topic><topic>Medical screening</topic><topic>Mortality</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Sickle cell disease</topic><topic>Stroke</topic><topic>Vaccines</topic><topic>Well being</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andong, Anne M</creatorcontrib><creatorcontrib>Ngouadjeu, Eveline D T</creatorcontrib><creatorcontrib>Bekolo, Cavin E</creatorcontrib><creatorcontrib>Verla, Vincent S</creatorcontrib><creatorcontrib>Nebongo, Daniel</creatorcontrib><creatorcontrib>Mboue-Djieka, Yannick</creatorcontrib><creatorcontrib>Choukem, Simeon-Pierre</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC blood disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andong, Anne M</au><au>Ngouadjeu, Eveline D T</au><au>Bekolo, Cavin E</au><au>Verla, Vincent S</au><au>Nebongo, Daniel</au><au>Mboue-Djieka, Yannick</au><au>Choukem, Simeon-Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study</atitle><jtitle>BMC blood disorders</jtitle><addtitle>BMC Hematol</addtitle><date>2017-04-20</date><risdate>2017</risdate><volume>17</volume><issue>1</issue><spage>7</spage><epage>7</epage><pages>7-7</pages><artnum>7</artnum><issn>2052-1839</issn><eissn>2052-1839</eissn><eissn>1471-2326</eissn><abstract>Sickle Cell Disease (SCD) is associated with chronic multisystem complications that significantly influence the quality of life (QOL) of patients early in their life. Although sub-Saharan Africa bears 75% of the global burden of SCD, there is a paucity of data on these complications and their effects on the QOL. We aimed to record these chronic complications, to estimate the QOL, and to identify the corresponding risk factors in patients with SCD receiving care in three hospitals in Cameroon.
In this cross-sectional study, a questionnaire was used to collect data from consecutive consenting patients. Information recorded included data on the yearly frequency of painful crisis, the types of SCD, and the occurrence of chronic complications. A 36-Item Short Form (SF-36) standard questionnaire that examines the level of physical and mental well-being, was administered to all eligible participants. Data were analyzed with STATA® software.
Of 175 participants included, 93 (53.1%) were female and 111 (aged ≥14 years) were eligible for QOL assessment. The median (interquartile range, IQR) age at diagnosis was 4.0 (2.0-8.0) years and the median (IQR) number of yearly painful crisis was 3.0 (1.0-7.0). The most frequent chronic complications reported were: nocturnal enuresis, chronic leg ulcers, osteomyelitis and priapism (30.9%, 24.6%, 19.4%, and 18.3% respectively). The prevalence of stroke and avascular necrosis of the hip were 8.0% and 13.1% respectively. The median (IQR) physical and mental scores were 47.3 (43.9-58.5) and 41.0 (38.8-44.6) respectively. Age and chronic complications such as stroke and avascular necrosis were independently associated with poor QOL.
In this population of patients living with SCD, chronic complications are frequent and their QOL is consequently poor. Our results highlight the need for national guidelines for SCD control, which should include new-born screening programs and strategies to prevent chronic complications.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>28439419</pmid><doi>10.1186/s12878-017-0079-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Anemia Cross-sectional studies Gangrene Hemoglobin Hospitals Leg ulcers Medical records Medical screening Mortality Quality of life Questionnaires Sickle cell disease Stroke Vaccines Well being |
| title | Chronic complications and quality of life of patients living with sickle cell disease and receiving care in three hospitals in Cameroon: a cross-sectional study |
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