Wnt signaling pathway in retinal vascularization

Wnt signaling pathway in retinal vascularization

Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Eye and brain 2016-01, Vol.8, p.141-146
1. Verfasser: Drenser, Kimberly A
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Cell adhesion & migration
Diabetic retinopathy
Genes
Ligands
Mutation
Proteins
Retina
Review
Signal transduction
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 146
container_issue
container_start_page 141
container_title Eye and brain
container_volume 8
creator Drenser, Kimberly A
description Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.
doi_str_mv 10.2147/EB.S94452
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5398754</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2226591810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-580b5aadad146966180aceb34a17fbeaa4a12d63920fe94634c49e036f356edd3</originalsourceid><addsrcrecordid>eNpdkU1Lw0AQhhdRbKk9-Ack4EUPqfud7EWwpX5AwYOKx2WabNot6abuJpX6601plepcZph5eHlnBqFzggeU8ORmPBy8KM4FPUJdQhIV04Tz44O6g_ohLHAbMpWCJKeoQ1PBVIpVF-F3V0fBzhyU1s2iFdTzT9hE1kXe1LbtRmsIWVOCt19Q28qdoZMCymD6-9xDb_fj19FjPHl-eBrdTeKMY1bHIsVTAZBDTrhUUpIUQ2amjANJiqkBaAuaS6YoLozikvGMK4OZLJiQJs9ZD93udFfNdGnyzLjaQ6lX3i7Bb3QFVv-dODvXs2qtt5slgrcCV3sBX300JtR6aUNmyhKcqZqgicKUJyoRqkUv_6GLqvHt8kFTSqVQJCW4pa53VOarELwpfs0QrLev0OOh3r2iZS8O3f-SP4dn3_a-g3M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2226591810</pqid></control><display><type>article</type><title>Wnt signaling pathway in retinal vascularization</title><source>Taylor &amp; Francis Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Dove Press Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Drenser, Kimberly A</creator><creatorcontrib>Drenser, Kimberly A</creatorcontrib><description>Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.</description><identifier>ISSN: 1179-2744</identifier><identifier>EISSN: 1179-2744</identifier><identifier>DOI: 10.2147/EB.S94452</identifier><identifier>PMID: 28539809</identifier><language>eng</language><publisher>New Zealand: Taylor &amp; Francis Ltd</publisher><subject>Angiogenesis ; Cell adhesion &amp; migration ; Diabetic retinopathy ; Genes ; Ligands ; Mutation ; Proteins ; Retina ; Review ; Signal transduction</subject><ispartof>Eye and brain, 2016-01, Vol.8, p.141-146</ispartof><rights>2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Drenser. This work is published and licensed by Dove Medical Press Limited 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-580b5aadad146966180aceb34a17fbeaa4a12d63920fe94634c49e036f356edd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398754/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398754/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,723,776,780,788,860,881,3849,27899,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28539809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drenser, Kimberly A</creatorcontrib><title>Wnt signaling pathway in retinal vascularization</title><title>Eye and brain</title><addtitle>Eye Brain</addtitle><description>Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.</description><subject>Angiogenesis</subject><subject>Cell adhesion &amp; migration</subject><subject>Diabetic retinopathy</subject><subject>Genes</subject><subject>Ligands</subject><subject>Mutation</subject><subject>Proteins</subject><subject>Retina</subject><subject>Review</subject><subject>Signal transduction</subject><issn>1179-2744</issn><issn>1179-2744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1Lw0AQhhdRbKk9-Ack4EUPqfud7EWwpX5AwYOKx2WabNot6abuJpX6601plepcZph5eHlnBqFzggeU8ORmPBy8KM4FPUJdQhIV04Tz44O6g_ohLHAbMpWCJKeoQ1PBVIpVF-F3V0fBzhyU1s2iFdTzT9hE1kXe1LbtRmsIWVOCt19Q28qdoZMCymD6-9xDb_fj19FjPHl-eBrdTeKMY1bHIsVTAZBDTrhUUpIUQ2amjANJiqkBaAuaS6YoLozikvGMK4OZLJiQJs9ZD93udFfNdGnyzLjaQ6lX3i7Bb3QFVv-dODvXs2qtt5slgrcCV3sBX300JtR6aUNmyhKcqZqgicKUJyoRqkUv_6GLqvHt8kFTSqVQJCW4pa53VOarELwpfs0QrLev0OOh3r2iZS8O3f-SP4dn3_a-g3M</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Drenser, Kimberly A</creator><general>Taylor &amp; Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Wnt signaling pathway in retinal vascularization</title><author>Drenser, Kimberly A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-580b5aadad146966180aceb34a17fbeaa4a12d63920fe94634c49e036f356edd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Angiogenesis</topic><topic>Cell adhesion &amp; migration</topic><topic>Diabetic retinopathy</topic><topic>Genes</topic><topic>Ligands</topic><topic>Mutation</topic><topic>Proteins</topic><topic>Retina</topic><topic>Review</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drenser, Kimberly A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye and brain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drenser, Kimberly A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt signaling pathway in retinal vascularization</atitle><jtitle>Eye and brain</jtitle><addtitle>Eye Brain</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>8</volume><spage>141</spage><epage>146</epage><pages>141-146</pages><issn>1179-2744</issn><eissn>1179-2744</eissn><abstract>Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.</abstract><cop>New Zealand</cop><pub>Taylor &amp; Francis Ltd</pub><pmid>28539809</pmid><doi>10.2147/EB.S94452</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1179-2744
ispartof Eye and brain, 2016-01, Vol.8, p.141-146
issn 1179-2744
1179-2744
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5398754
source Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; Dove Press Free; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Angiogenesis
Cell adhesion & migration
Diabetic retinopathy
Genes
Ligands
Mutation
Proteins
Retina
Review
Signal transduction
title Wnt signaling pathway in retinal vascularization
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T11%3A51%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Wnt%20signaling%20pathway%20in%20retinal%20vascularization&rft.jtitle=Eye%20and%20brain&rft.au=Drenser,%20Kimberly%20A&rft.date=2016-01-01&rft.volume=8&rft.spage=141&rft.epage=146&rft.pages=141-146&rft.issn=1179-2744&rft.eissn=1179-2744&rft_id=info:doi/10.2147/EB.S94452&rft_dat=%3Cproquest_pubme%3E2226591810%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2226591810&rft_id=info:pmid/28539809&rfr_iscdi=true