ERβ Selective Agonist Inhibits Angiotensin-Induced Cardiovascular Pathology in Female Mice

Cardiac hypertrophy in humans can progress to cardiac failure if the underlying impetus is poorly controlled. An important direct stimulator of hypertrophy and its progression is the angiotensin II (AngII) peptide. AngII also causes hypertension that indirectly contributes to cardiac hypertrophy. Ot...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-11, Vol.154 (11), p.4352-4364
Hauptverfasser:	Pedram, Ali, Razandi, Mahnaz, Korach, Kenneth S, Narayanan, Ramesh, Dalton, James T, Levin, Ellis R
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Agonists AKT protein Angiotensin Angiotensin II Angiotensins - toxicity Animals Biological and medical sciences Cardiomegaly - chemically induced Cardiomegaly - prevention & control Cardiovascular diseases Cardiovascular pathology Coronary artery disease Estradiol - pharmacology Estrogen Receptor beta - agonists Estrogen receptors Estrogens Female Females Fibrosis Fundamental and applied biological sciences. Psychology Gene expression Glycogen Glycogen synthase kinase 3 Glycogens Heart - drug effects Heart diseases Hypertension Hypertrophy Isoquinolines - pharmacology Kinases Malignancy Mice Myocardium - pathology Ovariectomy Pathology Receptors Renal-Cardiac-Vascular RNA, Messenger - genetics RNA, Messenger - metabolism Sex hormones Signal Transduction - drug effects Signal Transduction - physiology Stimulators Transcription activation Uterus Vertebrates: endocrinology
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