Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage

Oxidative DNA damage triggers telomere erosion and cellular senescence. However, how repair is initiated at telomeres is largely unknown. Here, we found unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telomeres is mainly dependent on tankyrase1 (TNKS1)...

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Veröffentlicht in:	Nucleic acids research 2017-04, Vol.45 (7), p.3906-3921
Hauptverfasser:	Yang, Lu, Sun, Luxi, Teng, Yaqun, Chen, Hao, Gao, Ying, Levine, Arthur S, Nakajima, Satoshi, Lan, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Survival DNA Damage DNA Repair Genome Integrity, Repair and Genomic Instability Humans Tankyrases - metabolism Telomere - enzymology Telomeric Repeat Binding Protein 1 - metabolism
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