Analyzing DNA curvature and its impact on the ionic environment: application to molecular dynamics simulations of minicircles

We propose a method for analyzing the magnitude and direction of curvature within nucleic acids, based on the curvilinear helical axis calculated by Curves+. The method is applied to analyzing curvature within minicircles constructed with varying degrees of over- or under-twisting. Using the molecul...

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Veröffentlicht in:	Nucleic acids research 2017-04, Vol.45 (7), p.4269-4277
Hauptverfasser:	Pasi, Marco, Zakrzewska, Krystyna, Maddocks, John H, Lavery, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA, Circular - chemistry Ions - chemistry Molecular Dynamics Simulation Potassium - chemistry Software Structural Biology
Online-Zugang:	Volltext
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