Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

Multiple sclerosis (MS) is an inflammatory CNS demyelinating disease in which remyelination largely fails. Transmembrane TNF (tmTNF) and TNF receptor 2 are important for remyelination in experimental MS models, but it is unknown whether soluble TNF (solTNF), a major proinflammatory factor, is involv...

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Veröffentlicht in:	JCI insight 2017-04, Vol.2 (8)
Hauptverfasser:	Karamita, Maria, Barnum, Christopher, Möbius, Wiebke, Tansey, Malú G, Szymkowski, David E, Lassmann, Hans, Probert, Lesley
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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