Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress

Isothiocyanates, such as phenethyl isothiocyanate (PEITC), are formed following the consumption of cruciferous vegetables and generate reactive oxygen species (ROS) that lead to the induction of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs). The induction of ROS activates the...

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Veröffentlicht in:	Scientific reports 2017-04, Vol.7 (1), p.46489, Article 46489
Hauptverfasser:	Yoda, Emiko, Paszek, Miles, Konopnicki, Camille, Fujiwara, Ryoichi, Chen, Shujuan, Tukey, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/77 38/90 631/208/135 64 64/60 692/4020/4021/288/2032 82 82/1 82/29 82/80 96 96/1 Acetylcysteine Animals Bilirubin Bilirubin - blood Gene Expression Regulation, Enzymologic - drug effects Genes Glucuronosyltransferase - biosynthesis Glucuronosyltransferase - genetics Humanities and Social Sciences Humans Intestine Isothiocyanate Isothiocyanates - pharmacology Liver Liver - metabolism Mice Mice, Transgenic multidisciplinary Neonates NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Phenethyl isothiocyanate Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Regulatory sequences Science Vegetables
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