Age‐Dependent Metabolic and Immunosuppressive Effects of Tacrolimus

Immunosuppression in elderly recipients has been underappreciated in clinical trials. Here, we assessed age‐specific effects of the calcineurin inhibitor tacrolimus (TAC) in a murine transplant model and assessed its clinical relevance on human T cells. Old recipient mice exhibited prolonged skin gr...

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Veröffentlicht in:	American journal of transplantation 2017-05, Vol.17 (5), p.1242-1254
Hauptverfasser:	Krenzien, F., Quante, M., Heinbokel, T., Seyda, M., Minami, K., Uehara, H., Biefer, H. R. C., Schuitenmaker, J. M., Gabardi, S., Splith, K., Schmelzle, M., Petrides, A. K., Azuma, H., Pratschke, J., Li, X. C., ElKhal, A., Tullius, S. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Animals basic (laboratory) research/science calcineurin inhibitor (CNI) CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Cells, Cultured Cytokines Cytokines - metabolism Graft Rejection - drug therapy Graft Rejection - etiology Graft Rejection - metabolism graft survival Graft Survival - drug effects Humans immunobiology immunosuppressant immunosuppression/immune modulation Immunosuppressive Agents - pharmacology Lymphocytes Male Mice Mice, Inbred C57BL Mice, Inbred DBA Skin & tissue grafts Skin Transplantation - adverse effects Tacrolimus - pharmacology translational research/science
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