Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates
Background: In clinical practice, bone mineral density (BMD) determined by dual-energy x-ray absorptiometry is used to monitor response to osteoporosis therapy. However, 1 to 2 yr are usually required to assess patients’ BMD responses. The possibility of earlier indicators of a response or nonrespon...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2009-04, Vol.94 (4), p.1097-1103 |
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| creator | Burnett-Bowie, Sherri-Ann M. Saag, Kenneth Sebba, Anthony de Papp, Anne E. Chen, Erluo Rosenberg, Elizabeth Greenspan, Susan L. |
| description | Background: In clinical practice, bone mineral density (BMD) determined by dual-energy x-ray absorptiometry is used to monitor response to osteoporosis therapy. However, 1 to 2 yr are usually required to assess patients’ BMD responses. The possibility of earlier indicators of a response or nonresponse to treatment, such as changes in bone turnover markers (BTMs), is of interest to physicians and patients.
Methods: In this post hoc analysis of women treated with once-weekly bisphosphonates, we examined the association of tertile percentage change from baseline in BTMs at 3 or 6 months and association of several baseline clinical characteristics with 24-month percentage change from baseline in BMD and with percentage of patients showing BMD nonresponse (defined as BMD loss at two or more of four sites) at 24 months. Multivariable analysis was performed to determine which factors were independently associated with BMD nonresponse.
Results: Patients in the tertile with the greatest decrease in each of the BTMs had the greatest mean increase in BMD and the lowest percentage of BMD nonresponders at 24 months. Several characteristics were independently associated with BMD nonresponse, including smaller 3-month reductions from baseline in serum C-terminal telopeptide of type 1 collagen, bone-specific alkaline phosphatase, and N-terminal propeptide of type 1 procollagen; younger age of menopause; a family history of osteoporosis; and higher baseline trochanteric BMD. Baseline BTMs were not predictive of 24-month BMD response to therapy. The strongest associations were for changes in BTMs with treatment.
Conclusion: In groups of patients, short-term changes in markers of bone turnover appear to be predictors of longer term BMD response and nonresponse to bisphosphonate therapy.
In groups of patients, short-term changes in bone turnover markers were predictive of longer term bone mineral density response and non-response to bisphosphonate therapy. |
| doi_str_mv | 10.1210/jc.2008-1122 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5393373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/jc.2008-1122</oup_id><sourcerecordid>3164433238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-8e4c71990dd5f80ebc68a16fcd458f09e8ca643a4ba5afd7c9bb1de6fc375b033</originalsourceid><addsrcrecordid>eNp1kd1rFDEUxYModq2--SwBEV86NXeSzMeLYNeqhUr7UKlvIZO50826m4zJTMv-92bYobWgDyEk98c953AIeQ3sGHJgH9bmOGesygDy_AlZQC1kVkJdPiULxnLI6jL_eUBexLhmDISQ_Dk5gBoEyJotiLsM2FozWO-o7-hypd0NRmodPfEO6XfrMOgN_Ywu2mE3_V_6OGzR-V6PMU2ufXrQq4B6wJbe2WFFL5zB7Brx12ZHT2zsV346LgHxJXnW6U3EV_N9SH58Ob1afsvOL76eLT-dZ0ZCMWQVCpMy1KxtZVcxbExRaSg60wpZdazGyuhCcC0aLXXXlqZuGmgxAbyUDeP8kHzc7-3HZoutQTekGKoPdqvDTnlt1eOJsyt142-V5DXn5bTg7bwg-N8jxkGt_Rhc8qw4FEJwnvMqUUd7ygQfY8DuXgGYmtpRa6OmdtTUTsLf_O3qAZ7rSMC7GdDR6E0XtDM23nM58ORPQuLe7zk_9v-TzGZJvifRtd6EVGcfMMaHNP80-geoZbdk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3164433238</pqid></control><display><type>article</type><title>Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Burnett-Bowie, Sherri-Ann M. ; Saag, Kenneth ; Sebba, Anthony ; de Papp, Anne E. ; Chen, Erluo ; Rosenberg, Elizabeth ; Greenspan, Susan L.</creator><creatorcontrib>Burnett-Bowie, Sherri-Ann M. ; Saag, Kenneth ; Sebba, Anthony ; de Papp, Anne E. ; Chen, Erluo ; Rosenberg, Elizabeth ; Greenspan, Susan L.</creatorcontrib><description>Background: In clinical practice, bone mineral density (BMD) determined by dual-energy x-ray absorptiometry is used to monitor response to osteoporosis therapy. However, 1 to 2 yr are usually required to assess patients’ BMD responses. The possibility of earlier indicators of a response or nonresponse to treatment, such as changes in bone turnover markers (BTMs), is of interest to physicians and patients.
Methods: In this post hoc analysis of women treated with once-weekly bisphosphonates, we examined the association of tertile percentage change from baseline in BTMs at 3 or 6 months and association of several baseline clinical characteristics with 24-month percentage change from baseline in BMD and with percentage of patients showing BMD nonresponse (defined as BMD loss at two or more of four sites) at 24 months. Multivariable analysis was performed to determine which factors were independently associated with BMD nonresponse.
Results: Patients in the tertile with the greatest decrease in each of the BTMs had the greatest mean increase in BMD and the lowest percentage of BMD nonresponders at 24 months. Several characteristics were independently associated with BMD nonresponse, including smaller 3-month reductions from baseline in serum C-terminal telopeptide of type 1 collagen, bone-specific alkaline phosphatase, and N-terminal propeptide of type 1 procollagen; younger age of menopause; a family history of osteoporosis; and higher baseline trochanteric BMD. Baseline BTMs were not predictive of 24-month BMD response to therapy. The strongest associations were for changes in BTMs with treatment.
Conclusion: In groups of patients, short-term changes in markers of bone turnover appear to be predictors of longer term BMD response and nonresponse to bisphosphonate therapy.
In groups of patients, short-term changes in bone turnover markers were predictive of longer term bone mineral density response and non-response to bisphosphonate therapy.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2008-1122</identifier><identifier>PMID: 19141590</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Alkaline phosphatase ; Biological and medical sciences ; Bisphosphonates ; Body Mass Index ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bone density ; Bone Density - drug effects ; Bone mineral density ; Bone turnover ; Continental Population Groups ; Diphosphonates - therapeutic use ; Dual energy X-ray absorptiometry ; Endocrine Care ; Endocrinopathies ; Ethnic Groups ; Feeding. Feeding behavior ; Female ; Fractures, Bone - epidemiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Medical sciences ; Menopause ; Middle Aged ; Osteoporosis ; Osteoporosis - prevention & control ; Patients ; Post-menopause ; Postmenopause - physiology ; Procollagen ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2009-04, Vol.94 (4), p.1097-1103</ispartof><rights>Copyright © 2009 by The Endocrine Society 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009 by The Endocrine Society</rights><rights>2009 by The Endocrine Society 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-8e4c71990dd5f80ebc68a16fcd458f09e8ca643a4ba5afd7c9bb1de6fc375b033</citedby><cites>FETCH-LOGICAL-c516t-8e4c71990dd5f80ebc68a16fcd458f09e8ca643a4ba5afd7c9bb1de6fc375b033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21353951$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19141590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burnett-Bowie, Sherri-Ann M.</creatorcontrib><creatorcontrib>Saag, Kenneth</creatorcontrib><creatorcontrib>Sebba, Anthony</creatorcontrib><creatorcontrib>de Papp, Anne E.</creatorcontrib><creatorcontrib>Chen, Erluo</creatorcontrib><creatorcontrib>Rosenberg, Elizabeth</creatorcontrib><creatorcontrib>Greenspan, Susan L.</creatorcontrib><title>Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Background: In clinical practice, bone mineral density (BMD) determined by dual-energy x-ray absorptiometry is used to monitor response to osteoporosis therapy. However, 1 to 2 yr are usually required to assess patients’ BMD responses. The possibility of earlier indicators of a response or nonresponse to treatment, such as changes in bone turnover markers (BTMs), is of interest to physicians and patients.
Methods: In this post hoc analysis of women treated with once-weekly bisphosphonates, we examined the association of tertile percentage change from baseline in BTMs at 3 or 6 months and association of several baseline clinical characteristics with 24-month percentage change from baseline in BMD and with percentage of patients showing BMD nonresponse (defined as BMD loss at two or more of four sites) at 24 months. Multivariable analysis was performed to determine which factors were independently associated with BMD nonresponse.
Results: Patients in the tertile with the greatest decrease in each of the BTMs had the greatest mean increase in BMD and the lowest percentage of BMD nonresponders at 24 months. Several characteristics were independently associated with BMD nonresponse, including smaller 3-month reductions from baseline in serum C-terminal telopeptide of type 1 collagen, bone-specific alkaline phosphatase, and N-terminal propeptide of type 1 procollagen; younger age of menopause; a family history of osteoporosis; and higher baseline trochanteric BMD. Baseline BTMs were not predictive of 24-month BMD response to therapy. The strongest associations were for changes in BTMs with treatment.
Conclusion: In groups of patients, short-term changes in markers of bone turnover appear to be predictors of longer term BMD response and nonresponse to bisphosphonate therapy.
In groups of patients, short-term changes in bone turnover markers were predictive of longer term bone mineral density response and non-response to bisphosphonate therapy.</description><subject>Alkaline phosphatase</subject><subject>Biological and medical sciences</subject><subject>Bisphosphonates</subject><subject>Body Mass Index</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bone density</subject><subject>Bone Density - drug effects</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Continental Population Groups</subject><subject>Diphosphonates - therapeutic use</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Endocrine Care</subject><subject>Endocrinopathies</subject><subject>Ethnic Groups</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fractures, Bone - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Osteoporosis - prevention & control</subject><subject>Patients</subject><subject>Post-menopause</subject><subject>Postmenopause - physiology</subject><subject>Procollagen</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd1rFDEUxYModq2--SwBEV86NXeSzMeLYNeqhUr7UKlvIZO50826m4zJTMv-92bYobWgDyEk98c953AIeQ3sGHJgH9bmOGesygDy_AlZQC1kVkJdPiULxnLI6jL_eUBexLhmDISQ_Dk5gBoEyJotiLsM2FozWO-o7-hypd0NRmodPfEO6XfrMOgN_Ywu2mE3_V_6OGzR-V6PMU2ufXrQq4B6wJbe2WFFL5zB7Brx12ZHT2zsV346LgHxJXnW6U3EV_N9SH58Ob1afsvOL76eLT-dZ0ZCMWQVCpMy1KxtZVcxbExRaSg60wpZdazGyuhCcC0aLXXXlqZuGmgxAbyUDeP8kHzc7-3HZoutQTekGKoPdqvDTnlt1eOJsyt142-V5DXn5bTg7bwg-N8jxkGt_Rhc8qw4FEJwnvMqUUd7ygQfY8DuXgGYmtpRa6OmdtTUTsLf_O3qAZ7rSMC7GdDR6E0XtDM23nM58ORPQuLe7zk_9v-TzGZJvifRtd6EVGcfMMaHNP80-geoZbdk</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Burnett-Bowie, Sherri-Ann M.</creator><creator>Saag, Kenneth</creator><creator>Sebba, Anthony</creator><creator>de Papp, Anne E.</creator><creator>Chen, Erluo</creator><creator>Rosenberg, Elizabeth</creator><creator>Greenspan, Susan L.</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates</title><author>Burnett-Bowie, Sherri-Ann M. ; Saag, Kenneth ; Sebba, Anthony ; de Papp, Anne E. ; Chen, Erluo ; Rosenberg, Elizabeth ; Greenspan, Susan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-8e4c71990dd5f80ebc68a16fcd458f09e8ca643a4ba5afd7c9bb1de6fc375b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alkaline phosphatase</topic><topic>Biological and medical sciences</topic><topic>Bisphosphonates</topic><topic>Body Mass Index</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - metabolism</topic><topic>Bone density</topic><topic>Bone Density - drug effects</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>Continental Population Groups</topic><topic>Diphosphonates - therapeutic use</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Endocrine Care</topic><topic>Endocrinopathies</topic><topic>Ethnic Groups</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fractures, Bone - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Osteoporosis</topic><topic>Osteoporosis - prevention & control</topic><topic>Patients</topic><topic>Post-menopause</topic><topic>Postmenopause - physiology</topic><topic>Procollagen</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burnett-Bowie, Sherri-Ann M.</creatorcontrib><creatorcontrib>Saag, Kenneth</creatorcontrib><creatorcontrib>Sebba, Anthony</creatorcontrib><creatorcontrib>de Papp, Anne E.</creatorcontrib><creatorcontrib>Chen, Erluo</creatorcontrib><creatorcontrib>Rosenberg, Elizabeth</creatorcontrib><creatorcontrib>Greenspan, Susan L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burnett-Bowie, Sherri-Ann M.</au><au>Saag, Kenneth</au><au>Sebba, Anthony</au><au>de Papp, Anne E.</au><au>Chen, Erluo</au><au>Rosenberg, Elizabeth</au><au>Greenspan, Susan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>94</volume><issue>4</issue><spage>1097</spage><epage>1103</epage><pages>1097-1103</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Background: In clinical practice, bone mineral density (BMD) determined by dual-energy x-ray absorptiometry is used to monitor response to osteoporosis therapy. However, 1 to 2 yr are usually required to assess patients’ BMD responses. The possibility of earlier indicators of a response or nonresponse to treatment, such as changes in bone turnover markers (BTMs), is of interest to physicians and patients.
Methods: In this post hoc analysis of women treated with once-weekly bisphosphonates, we examined the association of tertile percentage change from baseline in BTMs at 3 or 6 months and association of several baseline clinical characteristics with 24-month percentage change from baseline in BMD and with percentage of patients showing BMD nonresponse (defined as BMD loss at two or more of four sites) at 24 months. Multivariable analysis was performed to determine which factors were independently associated with BMD nonresponse.
Results: Patients in the tertile with the greatest decrease in each of the BTMs had the greatest mean increase in BMD and the lowest percentage of BMD nonresponders at 24 months. Several characteristics were independently associated with BMD nonresponse, including smaller 3-month reductions from baseline in serum C-terminal telopeptide of type 1 collagen, bone-specific alkaline phosphatase, and N-terminal propeptide of type 1 procollagen; younger age of menopause; a family history of osteoporosis; and higher baseline trochanteric BMD. Baseline BTMs were not predictive of 24-month BMD response to therapy. The strongest associations were for changes in BTMs with treatment.
Conclusion: In groups of patients, short-term changes in markers of bone turnover appear to be predictors of longer term BMD response and nonresponse to bisphosphonate therapy.
In groups of patients, short-term changes in bone turnover markers were predictive of longer term bone mineral density response and non-response to bisphosphonate therapy.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>19141590</pmid><doi>10.1210/jc.2008-1122</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2009-04, Vol.94 (4), p.1097-1103 |
| issn | 0021-972X 1945-7197 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alkaline phosphatase Biological and medical sciences Bisphosphonates Body Mass Index Bone and Bones - drug effects Bone and Bones - metabolism Bone density Bone Density - drug effects Bone mineral density Bone turnover Continental Population Groups Diphosphonates - therapeutic use Dual energy X-ray absorptiometry Endocrine Care Endocrinopathies Ethnic Groups Feeding. Feeding behavior Female Fractures, Bone - epidemiology Fundamental and applied biological sciences. Psychology Humans Medical sciences Menopause Middle Aged Osteoporosis Osteoporosis - prevention & control Patients Post-menopause Postmenopause - physiology Procollagen Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates |
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