Chlorinated Persistent Organic Pollutants, Obesity, and Type 2 Diabetes

Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and accumulate mainly in adipose tissue. Recent human evidence links low-dose POPs to an increased risk of type 2 diabetes (T2D). Because humans are contaminated by POP mixtures and POPs possibly have nonmonotonic...

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Veröffentlicht in:	Endocrine reviews 2014-08, Vol.35 (4), p.557-601
Hauptverfasser:	Lee, Duk-Hee, Porta, Miquel, Jacobs, David R, Vandenberg, Laura N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Animals Bioaccumulation Biomarkers Body fat Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Endocrine disruptors Environmental Pollutants - adverse effects Epidemiology Humans Hydrocarbons, Chlorinated - adverse effects Lipids Lipophilic Mixtures Obesity Obesity - epidemiology Obesity - etiology Obesity - physiopathology Organic Chemicals - adverse effects Organic compounds Organochlorine pesticides PCB Persistent organic pollutants Pesticides Pesticides - adverse effects Pollutants Polychlorinated biphenyls Polychlorinated Biphenyls - adverse effects Population studies Reviews Risk Factors
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