AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate

AMPA-type glutamate receptors (GluAs) mediate fast excitatory transmission in the vertebrate central nervous system (CNS), and their function has been extensively studied in the mature mammalian brain. However, GluA expression begins very early in developing embryos, suggesting that they may also ha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-04, Vol.114 (15), p.3939-3944
Hauptverfasser:	Hirai, Shinobu, Hotta, Kohji, Kubo, Yoshihiro, Nishino, Atsuo, Okabe, Shigeo, Okamura, Yasushi, Okado, Haruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Biological Sciences Brain Calcium Calcium - metabolism Central nervous system Ciona intestinalis Ciona intestinalis - genetics Ciona intestinalis - growth & development Ciona intestinalis - metabolism Defects Embryos Female Gene Expression Regulation, Developmental Gene Knockdown Techniques Genotype & phenotype Glutamic acid Glutamic acid receptors Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Larva Male Metamorphosis Morphogenesis Mutation Nervous system Oocytes - physiology Permeability Receptors Receptors, Glutamate - genetics Receptors, Glutamate - metabolism Rotating bodies Sense Organs - growth & development Sense Organs - metabolism Swimming Xenopus α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
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