Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44

Diverse protein import pathways into mitochondria use translocons on the outer membrane (TOM) and inner membrane (TIM). We adapted a genetic screen, based on Ura3 mistargeting from mitochondria to the cytosol, to identify small molecules that attenuated protein import. Small molecule mitochondrial i...

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Veröffentlicht in:	The Journal of biological chemistry 2017-03, Vol.292 (13), p.5429-5442
Hauptverfasser:	Miyata, Non, Tang, Zhiye, Conti, Michael A., Johnson, Meghan E., Douglas, Colin J., Hasson, Samuel A., Damoiseaux, Robert, Chang, Chia-en A., Koehler, Carla M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites chemical biology Genetic Testing HeLa Cells Humans Membrane Biology mitochondria Mitochondrial Membrane Transport Proteins - antagonists & inhibitors Mitochondrial Membrane Transport Proteins - chemistry Mitochondrial Membrane Transport Proteins - metabolism mitochondrial transport Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Neurospora crassa protein translocation Protein Transport - drug effects Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism small molecule Zebrafish
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