Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS

Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker in MS, the most common demyelinating disease of the CNS. We have attempted to identify the B cell subpopulation responsible for oligoclonal IgM secretion and the specificity of these bands. In addition, we e...

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Veröffentlicht in:	The Journal of clinical investigation 2005-01, Vol.115 (1), p.187-194
Hauptverfasser:	Villar, Luisa M, Sádaba, María C, Roldán, Ernesto, Masjuan, Jaime, González-Porqué, Pedro, Villarrubia, Noelia, Espiño, Mercedes, García-Trujillo, José A, Bootello, Alfredo, Alvarez-Cermeño, José C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies Antibody Specificity B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedical research Cerebrospinal fluid Cerebrospinal Fluid - immunology Disease Female Follow-Up Studies Humans Immunoglobulin M - biosynthesis Immunoglobulin M - immunology Immunophenotyping Lipids Lipids - immunology Lymphocytes Male Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Myelin Sheath - chemistry Myelin Sheath - immunology Oligoclonal Bands - biosynthesis Oligoclonal Bands - immunology Patients Prognosis Proteins Survival Rate
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