Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy

The introduction of highly active antiretroviral therapy (HAART) has significantly decreased morbidity and mortality among patients infected with HIV-1. However, HIV-1 can acquire resistance against all currently available antiretroviral drugs targeting viral reverse transcriptase, protease, and gp4...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2005-01, Vol.115 (1), p.76-85
Hauptverfasser:	Hauber, Ilona, Bevec, Dorian, Heukeshoven, Jochen, Krätzer, Friedrich, Horn, Florian, Choidas, Axel, Harrer, Thomas, Hauber, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Biological activity Biomedical research Cell cycle Cells, Cultured Drug resistance Drug Resistance, Multiple Drug therapy Enzymes Gene Expression Regulation, Viral - drug effects Gene Products, rev - metabolism HIV Infections - drug therapy HIV Infections - enzymology HIV Infections - virology HIV-1 - drug effects HIV-1 - physiology Humans Hydrazones - chemistry Hydrazones - pharmacology Kinases Kinetics Lysine - analogs & derivatives Lysine - metabolism Macrophages - drug effects Macrophages - virology Molecular weight Mortality Oxidoreductases Acting on CH-NH Group Donors - antagonists & inhibitors Oxidoreductases Acting on CH-NH Group Donors - genetics Oxidoreductases Acting on CH-NH Group Donors - metabolism Phenotype Proteins rev Gene Products, Human Immunodeficiency Virus RNA Interference T-Lymphocytes - drug effects T-Lymphocytes - virology Transcriptional Activation - drug effects Virus Replication - drug effects Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!