Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus

Hypercholesterolemia is a well known risk factor for the development of neurodegenerative disease. However, the underlying mechanisms are mostly unknown. In recent years, it has become increasingly evident that cholesterol-driven effects on physiology and pathophysiology derive from its ability to a...

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Veröffentlicht in:	The Journal of biological chemistry 2017-04, Vol.292 (15), p.6135-6147
Hauptverfasser:	Bukiya, Anna N., Durdagi, Serdar, Noskov, Sergei, Rosenhouse-Dantsker, Avia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CA1 Region, Hippocampal - chemistry CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - metabolism cholesterol Cholesterol - chemistry Cholesterol - metabolism cholesterol-induced channel activation electrophysiology G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism G protein-gated inwardly rectifying potassium channel hippocampal CA1 pyramidal neurons Ion Channel Gating - physiology lipid bilayer Lipid Bilayers - chemistry lipid-protein interaction Male Molecular Biophysics molecular docking neuron Oocytes Protein Domains Pyramidal Cells - chemistry Pyramidal Cells - cytology Pyramidal Cells - metabolism Rats Rats, Sprague-Dawley structure-function Up-Regulation - physiology Xenopus
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