LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration

Nonmuscle myosin II (NM-II) is an important motor protein involved in cell migration. Incorporation of NM-II into actin stress fiber provides a traction force to promote actin retrograde flow and focal adhesion assembly. However, the components involved in regulation of NM-II activity are not well u...

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Veröffentlicht in:	Molecular biology of the cell 2017-04, Vol.28 (8), p.1054-1065
Hauptverfasser:	Lin, Yu-Hung, Zhen, Yen-Yi, Chien, Kun-Yi, Lee, I-Ching, Lin, Wei-Chi, Chen, Mei-Yu, Pai, Li-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actinin - metabolism Cell Adhesion - physiology Cell Line, Tumor Cell Movement - physiology Cytoskeleton - metabolism Focal Adhesions - metabolism HeLa Cells Humans LIM Domain Proteins - metabolism Myosin Light Chains - metabolism Nonmuscle Myosin Type IIA - metabolism Phosphorylation Stress Fibers - metabolism Stress Fibers - physiology
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