Monocyte Chemotactic Protein-1–Interleukin-6–Osteopontin Pathway of Intra-Aneurysmal Tissue Healing

BACKGROUND AND PURPOSE—We have previously demonstrated that the local delivery of monocyte chemotactic protein-1 (MCP-1) via an MCP-1–releasing poly(lactic-co-glycolic acid)–coated coil promotes intra-aneurysmal tissue healing. In this study, we demonstrate that interleukin-6 (IL-6) and osteopontin...

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Veröffentlicht in:	Stroke (1970) 2017-04, Vol.48 (4), p.1052-1060
Hauptverfasser:	Hosaka, Koji, Rojas, Kelley, Fazal, Hanain Z, Schneider, Matheus B, Shores, Jorma, Federico, Vincent, McCord, Matthew, Lin, Li, Hoh, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Blocking - metabolism Biocompatible Materials - therapeutic use Chemokine CCL2 - administration & dosage Chemokine CCL2 - pharmacology Disease Models, Animal Embolization, Therapeutic Humans Interleukin-6 - administration & dosage Interleukin-6 - pharmacology Intracranial Aneurysm - drug therapy Intracranial Aneurysm - therapy Lactic Acid - therapeutic use Mice Mice, Inbred C57BL Osteopontin - administration & dosage Osteopontin - pharmacology Polyglycolic Acid - therapeutic use
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