Increasing Thyromimetic Potency through Halogen Substitution

Sobetirome is one of the most studied thyroid hormone receptor β (TRβ)‐selective thyromimetics in the field due to its excellent selectivity and potency. A small structural change—replacing the 3,5‐dimethyl groups of sobetirome with either chlorine or bromine—produces significantly more potent compo...

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Veröffentlicht in:	ChemMedChem 2016-11, Vol.11 (21), p.2459-2465
Hauptverfasser:	Devereaux, Jordan, Ferrara, Skylar J., Banerji, Tania, Placzek, Andrew T., Scanlan, Thomas S.
Format:	Artikel
Sprache:	eng
Schlagworte:	brain central nervous system Thyroid gland thyroid hormones thyromimetics
Online-Zugang:	Volltext
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