Post-absorptive muscle protein turnover affects resistance training hypertrophy
Purpose Acute bouts of resistance exercise and subsequent training alters protein turnover in skeletal muscle. The mechanisms responsible for the changes in basal post-absorptive protein turnover and its impact on muscle hypertrophy following resistance exercise training are unknown. Our goal was to...
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| Veröffentlicht in: | European journal of applied physiology 2017-05, Vol.117 (5), p.853-866 |
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| creator | Reidy, Paul T. Borack, Michael S. Markofski, Melissa M. Dickinson, Jared M. Fry, Christopher S. Deer, Rachel R. Volpi, Elena Rasmussen, Blake B. |
| description | Purpose
Acute bouts of resistance exercise and subsequent training alters protein turnover in skeletal muscle. The mechanisms responsible for the changes in basal post-absorptive protein turnover and its impact on muscle hypertrophy following resistance exercise training are unknown. Our goal was to determine whether post-absorptive muscle protein turnover following 12 weeks of resistance exercise training (RET) plays a role in muscle hypertrophy. In addition, we were interested in determining potential molecular mechanisms responsible for altering post-training muscle protein turnover.
Methods
Healthy young men (
n
= 31) participated in supervised whole body progressive RET at 60–80% 1 repetition maximum (1-RM), 3 days/week for 3 months. Pre- and post-training
vastus lateralis
muscle biopsies and blood samples taken during an infusion of
13
C
6
and
15
N phenylalanine and were used to assess skeletal muscle protein turnover in the post-absorptive state. Lean body mass (LBM), muscle strength (determined by dynamometry),
vastus lateralis
muscle thickness (MT), myofiber type-specific cross-sectional area (CSA), and mRNA were assessed pre- and post-RET.
Results
RET increased strength (12–40%), LBM (~5%), MT (~15%) and myofiber CSA (~20%) (
p
|
| doi_str_mv | 10.1007/s00421-017-3566-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5389914</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321629911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c617t-d4a23884cabc33ac2097274db43d77173290afd9f1280ab6f7a9ebe50de8450c3</originalsourceid><addsrcrecordid>eNqNkV9LHDEUxUOpVF37AfpSBvrSl9H8m0nyIoi0Kgj2oT6HTObObmQ2mSaZhf32Zlm72ILgUwL3l5Nzz0HoC8HnBGNxkTDmlNSYiJo1bVvzD-iEcKbqllHx8XAn6hidpvSEMZaUyE_omEoqsRL8BD38CinXpkshTtltoFrPyY5QTTFkcL7Kc_RhA7EywwA2pypCcikbb6HK0Tjv_LJabSeIOYZptT1DR4MZE3x-ORfo8eeP39e39f3Dzd311X1tWyJy3XNDmZTcms4yZiwtbqjgfcdZLwQRjCpshl4NpBg1XTsIo6CDBvcgeYMtW6DLve40d2voLfjiZtRTdGsTtzoYp_-deLfSy7DRDZNKlWAW6PuLQAx_ZkhZr12yMI7GQ5iTJlIRKRumyDtQ0XLFuaIF_fYf-hRKgiWJQsm2kQRLWSiyp2wMKUUYDr4J1rtm9b5ZXZrVu2b1zu_X1wsfXvytsgB0D6Qy8kuIr75-U_UZB7ewNA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1886581088</pqid></control><display><type>article</type><title>Post-absorptive muscle protein turnover affects resistance training hypertrophy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Reidy, Paul T. ; Borack, Michael S. ; Markofski, Melissa M. ; Dickinson, Jared M. ; Fry, Christopher S. ; Deer, Rachel R. ; Volpi, Elena ; Rasmussen, Blake B.</creator><creatorcontrib>Reidy, Paul T. ; Borack, Michael S. ; Markofski, Melissa M. ; Dickinson, Jared M. ; Fry, Christopher S. ; Deer, Rachel R. ; Volpi, Elena ; Rasmussen, Blake B.</creatorcontrib><description>Purpose
Acute bouts of resistance exercise and subsequent training alters protein turnover in skeletal muscle. The mechanisms responsible for the changes in basal post-absorptive protein turnover and its impact on muscle hypertrophy following resistance exercise training are unknown. Our goal was to determine whether post-absorptive muscle protein turnover following 12 weeks of resistance exercise training (RET) plays a role in muscle hypertrophy. In addition, we were interested in determining potential molecular mechanisms responsible for altering post-training muscle protein turnover.
Methods
Healthy young men (
n
= 31) participated in supervised whole body progressive RET at 60–80% 1 repetition maximum (1-RM), 3 days/week for 3 months. Pre- and post-training
vastus lateralis
muscle biopsies and blood samples taken during an infusion of
13
C
6
and
15
N phenylalanine and were used to assess skeletal muscle protein turnover in the post-absorptive state. Lean body mass (LBM), muscle strength (determined by dynamometry),
vastus lateralis
muscle thickness (MT), myofiber type-specific cross-sectional area (CSA), and mRNA were assessed pre- and post-RET.
Results
RET increased strength (12–40%), LBM (~5%), MT (~15%) and myofiber CSA (~20%) (
p
< 0.05). Muscle protein synthesis (MPS) increased 24% while muscle protein breakdown (MPB) decreased 21%, respectively. These changes in protein turnover resulted in an improved net muscle protein balance in the basal state following RET. Further, the change in basal MPS is positively associated (
r
= 0.555,
p
= 0.003) with the change in muscle thickness.
Conclusion
Post-absorptive muscle protein turnover is associated with muscle hypertrophy during resistance exercise training.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-017-3566-4</identifier><identifier>PMID: 28280974</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Absorptiometry, Photon ; Autophagy ; Biomedical and Life Sciences ; Biomedicine ; Biosynthesis ; Cyclin-dependent kinases ; Exercise ; Fitness training programs ; Human Physiology ; Humans ; Kinases ; Male ; Muscle Proteins - metabolism ; Muscle Strength ; Musculoskeletal system ; Occupational Medicine/Industrial Medicine ; Original Article ; Physical fitness ; Protein synthesis ; Proteins ; Quadriceps Muscle - diagnostic imaging ; Quadriceps Muscle - metabolism ; Quadriceps Muscle - physiology ; Resistance Training ; Ribonucleic acid ; RNA ; Sports Medicine ; Strength training ; Transcription factors ; Yeast ; Young Adult</subject><ispartof>European journal of applied physiology, 2017-05, Vol.117 (5), p.853-866</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>European Journal of Applied Physiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-d4a23884cabc33ac2097274db43d77173290afd9f1280ab6f7a9ebe50de8450c3</citedby><cites>FETCH-LOGICAL-c617t-d4a23884cabc33ac2097274db43d77173290afd9f1280ab6f7a9ebe50de8450c3</cites><orcidid>0000-0001-7854-5375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-017-3566-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-017-3566-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28280974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reidy, Paul T.</creatorcontrib><creatorcontrib>Borack, Michael S.</creatorcontrib><creatorcontrib>Markofski, Melissa M.</creatorcontrib><creatorcontrib>Dickinson, Jared M.</creatorcontrib><creatorcontrib>Fry, Christopher S.</creatorcontrib><creatorcontrib>Deer, Rachel R.</creatorcontrib><creatorcontrib>Volpi, Elena</creatorcontrib><creatorcontrib>Rasmussen, Blake B.</creatorcontrib><title>Post-absorptive muscle protein turnover affects resistance training hypertrophy</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
Acute bouts of resistance exercise and subsequent training alters protein turnover in skeletal muscle. The mechanisms responsible for the changes in basal post-absorptive protein turnover and its impact on muscle hypertrophy following resistance exercise training are unknown. Our goal was to determine whether post-absorptive muscle protein turnover following 12 weeks of resistance exercise training (RET) plays a role in muscle hypertrophy. In addition, we were interested in determining potential molecular mechanisms responsible for altering post-training muscle protein turnover.
Methods
Healthy young men (
n
= 31) participated in supervised whole body progressive RET at 60–80% 1 repetition maximum (1-RM), 3 days/week for 3 months. Pre- and post-training
vastus lateralis
muscle biopsies and blood samples taken during an infusion of
13
C
6
and
15
N phenylalanine and were used to assess skeletal muscle protein turnover in the post-absorptive state. Lean body mass (LBM), muscle strength (determined by dynamometry),
vastus lateralis
muscle thickness (MT), myofiber type-specific cross-sectional area (CSA), and mRNA were assessed pre- and post-RET.
Results
RET increased strength (12–40%), LBM (~5%), MT (~15%) and myofiber CSA (~20%) (
p
< 0.05). Muscle protein synthesis (MPS) increased 24% while muscle protein breakdown (MPB) decreased 21%, respectively. These changes in protein turnover resulted in an improved net muscle protein balance in the basal state following RET. Further, the change in basal MPS is positively associated (
r
= 0.555,
p
= 0.003) with the change in muscle thickness.
Conclusion
Post-absorptive muscle protein turnover is associated with muscle hypertrophy during resistance exercise training.</description><subject>Absorptiometry, Photon</subject><subject>Autophagy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biosynthesis</subject><subject>Cyclin-dependent kinases</subject><subject>Exercise</subject><subject>Fitness training programs</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Kinases</subject><subject>Male</subject><subject>Muscle Proteins - metabolism</subject><subject>Muscle Strength</subject><subject>Musculoskeletal system</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Physical fitness</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Quadriceps Muscle - diagnostic imaging</subject><subject>Quadriceps Muscle - metabolism</subject><subject>Quadriceps Muscle - physiology</subject><subject>Resistance Training</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Sports Medicine</subject><subject>Strength training</subject><subject>Transcription factors</subject><subject>Yeast</subject><subject>Young Adult</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV9LHDEUxUOpVF37AfpSBvrSl9H8m0nyIoi0Kgj2oT6HTObObmQ2mSaZhf32Zlm72ILgUwL3l5Nzz0HoC8HnBGNxkTDmlNSYiJo1bVvzD-iEcKbqllHx8XAn6hidpvSEMZaUyE_omEoqsRL8BD38CinXpkshTtltoFrPyY5QTTFkcL7Kc_RhA7EywwA2pypCcikbb6HK0Tjv_LJabSeIOYZptT1DR4MZE3x-ORfo8eeP39e39f3Dzd311X1tWyJy3XNDmZTcms4yZiwtbqjgfcdZLwQRjCpshl4NpBg1XTsIo6CDBvcgeYMtW6DLve40d2voLfjiZtRTdGsTtzoYp_-deLfSy7DRDZNKlWAW6PuLQAx_ZkhZr12yMI7GQ5iTJlIRKRumyDtQ0XLFuaIF_fYf-hRKgiWJQsm2kQRLWSiyp2wMKUUYDr4J1rtm9b5ZXZrVu2b1zu_X1wsfXvytsgB0D6Qy8kuIr75-U_UZB7ewNA</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Reidy, Paul T.</creator><creator>Borack, Michael S.</creator><creator>Markofski, Melissa M.</creator><creator>Dickinson, Jared M.</creator><creator>Fry, Christopher S.</creator><creator>Deer, Rachel R.</creator><creator>Volpi, Elena</creator><creator>Rasmussen, Blake B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7854-5375</orcidid></search><sort><creationdate>20170501</creationdate><title>Post-absorptive muscle protein turnover affects resistance training hypertrophy</title><author>Reidy, Paul T. ; Borack, Michael S. ; Markofski, Melissa M. ; Dickinson, Jared M. ; Fry, Christopher S. ; Deer, Rachel R. ; Volpi, Elena ; Rasmussen, Blake B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-d4a23884cabc33ac2097274db43d77173290afd9f1280ab6f7a9ebe50de8450c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Absorptiometry, Photon</topic><topic>Autophagy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biosynthesis</topic><topic>Cyclin-dependent kinases</topic><topic>Exercise</topic><topic>Fitness training programs</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Kinases</topic><topic>Male</topic><topic>Muscle Proteins - metabolism</topic><topic>Muscle Strength</topic><topic>Musculoskeletal system</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Physical fitness</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Quadriceps Muscle - diagnostic imaging</topic><topic>Quadriceps Muscle - metabolism</topic><topic>Quadriceps Muscle - physiology</topic><topic>Resistance Training</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Sports Medicine</topic><topic>Strength training</topic><topic>Transcription factors</topic><topic>Yeast</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reidy, Paul T.</creatorcontrib><creatorcontrib>Borack, Michael S.</creatorcontrib><creatorcontrib>Markofski, Melissa M.</creatorcontrib><creatorcontrib>Dickinson, Jared M.</creatorcontrib><creatorcontrib>Fry, Christopher S.</creatorcontrib><creatorcontrib>Deer, Rachel R.</creatorcontrib><creatorcontrib>Volpi, Elena</creatorcontrib><creatorcontrib>Rasmussen, Blake B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reidy, Paul T.</au><au>Borack, Michael S.</au><au>Markofski, Melissa M.</au><au>Dickinson, Jared M.</au><au>Fry, Christopher S.</au><au>Deer, Rachel R.</au><au>Volpi, Elena</au><au>Rasmussen, Blake B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-absorptive muscle protein turnover affects resistance training hypertrophy</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>117</volume><issue>5</issue><spage>853</spage><epage>866</epage><pages>853-866</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
Acute bouts of resistance exercise and subsequent training alters protein turnover in skeletal muscle. The mechanisms responsible for the changes in basal post-absorptive protein turnover and its impact on muscle hypertrophy following resistance exercise training are unknown. Our goal was to determine whether post-absorptive muscle protein turnover following 12 weeks of resistance exercise training (RET) plays a role in muscle hypertrophy. In addition, we were interested in determining potential molecular mechanisms responsible for altering post-training muscle protein turnover.
Methods
Healthy young men (
n
= 31) participated in supervised whole body progressive RET at 60–80% 1 repetition maximum (1-RM), 3 days/week for 3 months. Pre- and post-training
vastus lateralis
muscle biopsies and blood samples taken during an infusion of
13
C
6
and
15
N phenylalanine and were used to assess skeletal muscle protein turnover in the post-absorptive state. Lean body mass (LBM), muscle strength (determined by dynamometry),
vastus lateralis
muscle thickness (MT), myofiber type-specific cross-sectional area (CSA), and mRNA were assessed pre- and post-RET.
Results
RET increased strength (12–40%), LBM (~5%), MT (~15%) and myofiber CSA (~20%) (
p
< 0.05). Muscle protein synthesis (MPS) increased 24% while muscle protein breakdown (MPB) decreased 21%, respectively. These changes in protein turnover resulted in an improved net muscle protein balance in the basal state following RET. Further, the change in basal MPS is positively associated (
r
= 0.555,
p
= 0.003) with the change in muscle thickness.
Conclusion
Post-absorptive muscle protein turnover is associated with muscle hypertrophy during resistance exercise training.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28280974</pmid><doi>10.1007/s00421-017-3566-4</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-7854-5375</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2017-05, Vol.117 (5), p.853-866 |
| issn | 1439-6319 1439-6327 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Absorptiometry, Photon Autophagy Biomedical and Life Sciences Biomedicine Biosynthesis Cyclin-dependent kinases Exercise Fitness training programs Human Physiology Humans Kinases Male Muscle Proteins - metabolism Muscle Strength Musculoskeletal system Occupational Medicine/Industrial Medicine Original Article Physical fitness Protein synthesis Proteins Quadriceps Muscle - diagnostic imaging Quadriceps Muscle - metabolism Quadriceps Muscle - physiology Resistance Training Ribonucleic acid RNA Sports Medicine Strength training Transcription factors Yeast Young Adult |
| title | Post-absorptive muscle protein turnover affects resistance training hypertrophy |
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