Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury

The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective mechanism derives from FcRn binding to IgG in the weakly acidic environment contai...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-04, Vol.114 (14), p.E2862-E2871
Hauptverfasser:	Pyzik, Michal, Rath, Timo, Kuo, Timothy T., Win, Sanda, Baker, Kristi, Hubbard, Jonathan J., Grenha, Rosa, Gandhi, Amit, Krämer, Thomas D., Mezo, Adam R., Taylor, Zachary S., McDonnell, Kevin, Nienaber, Vicki, Andersen, Jan Terje, Mizoguchi, Atsushi, Blumberg, Laurence, Purohit, Shalaka, Jones, Susan D., Christianson, Greg, Lencer, Wayne I., Sandlie, Inger, Kaplowitz, Neil, Roopenian, Derry C., Blumberg, Richard S.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acetaminophen - adverse effects Acetaminophen - metabolism albumin Albumins - metabolism Animals bile Bile - metabolism Biological Sciences Cells Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Dogs FcRn Female Hepatocytes - metabolism Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Homeostasis Liver Liver diseases Madin Darby Canine Kidney Cells Male Mice, Inbred BALB C Mice, Inbred C57BL Mice, Mutant Strains Monoclonal antibodies Peptides PNAS Plus Protected species Proteins Receptors, Fc - genetics Receptors, Fc - metabolism Serum Albumin, Human - genetics Serum Albumin, Human - metabolism Toxicity toxin Transcytosis - genetics
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