Fatty acid 16:4(n‐3) stimulates a GPR120‐induced signaling cascade in splenic macrophages to promote chemotherapy resistance

ABSTRACT Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum‐induced fatty acid 16: 4(n‐3) (hexadeca‐4,7,10,13‐tetraenoic acid) induces systemic resistance to a broad range of DNA‐damaging chemotherapeutics. We show that 16: 4(n...

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Veröffentlicht in:	The FASEB journal 2017-05, Vol.31 (5), p.2195-2209
Hauptverfasser:	Houthuijzen, Julia M., Oosterom, Ilse, Hudson, Brian D., Hirasawa, Akira, Daenen, Laura G. M., McLean, Chelsea M., Hansen, Steffen V. F., Jaarsveld, Marijn T. M., Peeper, Daniel S., Sadatmand, Sahar Jafari, Roodhart, Jeanine M. L., Lest, Chris H. A., Ulven, Trond, Ishihara, Kenji, Milligan, Graeme, Voest, Emile E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Animal tissues Animals CD11b antigen Chemoresistance Chemotherapy Deoxyribonucleic acid DNA DNA damage Drug Resistance - physiology Fatty acids Fatty Acids, Omega-3 - metabolism FFAR1 FFAR4 GPR40 Lysophosphatidylcholine Macrophages Macrophages - metabolism Mice, Inbred BALB C Pharmacology PIFA Platinum Receptors, G-Protein-Coupled - metabolism Secretion Signal Transduction - physiology Signaling Spleen Splenocytes Tumor cells
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