Nucleobase modification by an RNA enzyme

Ribozymes can catalyze phosphoryl or nucleotidyl transfer onto ribose hydroxyls of RNA chains. We report a single ribozyme that performs both reactions, with a nucleobase serving as initial acceptor moiety. This unprecedented combined reaction was revealed while investigating potential contributions...

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Veröffentlicht in:	Nucleic acids research 2017-02, Vol.45 (3), p.1345-1354
Hauptverfasser:	Poudyal, Raghav R, Nguyen, Phuong D M, Lokugamage, Melissa P, Callaway, Mackenzie K, Gavette, Jesse V, Krishnamurthy, Ramanarayanan, Burke, Donald H
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Catalysis Evolution, Molecular Guanosine - chemistry Hydrogen-Ion Concentration Kinetics Nucleic Acid Conformation Nucleic Acid Enzymes Phosphorylation RNA - chemistry RNA - metabolism RNA Stability RNA, Catalytic - chemistry RNA, Catalytic - metabolism Substrate Specificity Synthetic Biology Temperature
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