Complex pectin metabolism by gut bacteria reveals novel catalytic functions

The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single organisms are required to depolymerize highly complex glycans. Here we show that the gut bacterium Bacteroides thetaiotaomicron uses the most...

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Veröffentlicht in:	Nature (London) 2017-04, Vol.544 (7648), p.65-70
Hauptverfasser:	Ndeh, Didier, Rogowski, Artur, Cartmell, Alan, Luis, Ana S., Baslé, Arnaud, Gray, Joseph, Venditto, Immacolata, Briggs, Jonathon, Zhang, Xiaoyang, Labourel, Aurore, Terrapon, Nicolas, Buffetto, Fanny, Nepogodiev, Sergey, Xiao, Yao, Field, Robert A., Zhu, Yanping, O’Neill, Malcolm A., Urbanowicz, Breeanna R., York, William S., Davies, Gideon J., Abbott, D. Wade, Ralet, Marie-Christine, Martens, Eric C., Henrissat, Bernard, Gilbert, Harry J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326 631/45/221 82 82/83 Acids Analysis Bacteroides thetaiotaomicron - enzymology Bacteroides thetaiotaomicron - growth & development Bacteroides thetaiotaomicron - metabolism BASIC BIOLOGICAL SCIENCES Biocatalysis Borates - chemistry Borates - metabolism Catalysis Catalytic Domain Crystal structure Enzymes Gastrointestinal Microbiome Gastrointestinal Tract - microbiology Glycoside Hydrolases - chemistry Glycoside Hydrolases - classification Glycoside Hydrolases - metabolism Humanities and Social Sciences Humans Life Sciences Microbiota (Symbiotic organisms) Models, Molecular multidisciplinary Mutagenesis Pectin Pectins - chemistry Pectins - metabolism Physiological aspects Science Studies Substrate Specificity Vegetal Biology
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